槟城线蕨根茎的神经活性成分。

Neuropective constituents from the rhizomes of Abacopteris penangiana.

作者信息

Wei Han, Wu Guang-Hua, Lei Yong-Fang, Xiong Chao-Mei, Ruan Jin-Lan

机构信息

Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation of Hubei Province, Tongji Medical Center, College of Pharmacy, Huazhong University of Science and Technology, Wuhan, China.

出版信息

J Asian Nat Prod Res. 2011 Aug;13(8):707-13. doi: 10.1080/10286020.2011.586340.

DOI:10.1080/10286020.2011.586340

PMID:21751838

Abstract

Two neuropective compounds were isolated from the rhizomes of Abacopteris penangiana, one was a new flavone and the other was a flavanone. Both compounds were firstly separated from natural plant. The isolation work was guided by the antioxidant activity. Both the compounds showed a significant antioxidant activity in vitro and a protective effect on dopamine-induced neurotoxicity in PC12 cells.

摘要

从槟城阿坝蕨的根茎中分离出两种神经活性化合物，一种是新黄酮，另一种是黄烷酮。这两种化合物均首次从天然植物中分离得到。分离工作以抗氧化活性为导向。这两种化合物在体外均表现出显著的抗氧化活性，并对PC12细胞中多巴胺诱导的神经毒性具有保护作用。