来自内生旋孢腔菌属的神经氨酸酶抑制性萜类化合物

Neuraminidase inhibitory terpenes from endophytic Cochliobolus sp.

作者信息

Zhang Gao-Fei, Guo Zhi-Kai, Wang Wei, Cui Jiang-Tao, Tan Ren-Xiang, Ge Hui-Ming

机构信息

State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing, China.

出版信息

J Asian Nat Prod Res. 2011 Aug;13(8):761-4. doi: 10.1080/10286020.2011.585608.

DOI:10.1080/10286020.2011.585608

PMID:21751846

Abstract

The chemical study of endophytic fungus of Cochliobolus led to the isolation of 10 terpenes (1-10), including one new compound named isocochlioquinone B (1). Their structures were elucidated on the basis of spectroscopic methods, including 2D NMR techniques. Compounds 5-7 showed significant neuraminidase inhibitory activity with IC(50) values of 0.79-1.75 μM.

摘要

对旋孢腔菌内生真菌的化学研究导致分离出10种萜类化合物（1-10），包括一种名为异旋孢醌B（1）的新化合物。它们的结构通过光谱方法得以阐明，包括二维核磁共振技术。化合物5-7表现出显著的神经氨酸酶抑制活性，IC(50)值为0.79-1.75μM。