Inserm-EPHE-Université de Caen/Basse-Normandie, Unité U923, GIP Cyceron, CHU Côte de Nacre, Caen, France.
J Neuroimaging. 2011 Oct;21(4):310-6. doi: 10.1111/j.1552-6569.2010.00548.x. Epub 2011 Jul 13.
To provide guidance regarding the most appropriate voxel-based morphometry (VBM)-derived method for assessing hippocampal atrophy in early Alzheimer's disease (AD).
T1-MRI volume data were collected in 23 patients with amnestic mild cognitive impairment (aMCI) and 18 controls. Three types of data (unmodulated and 2 types of modulated MRI) and 2 extraction methods (with reference to the hippocampal peak of atrophy identified from a preliminary whole-brain analysis, or using a template region of interest-ROI-approach) were compared to the gold-standard individual ROI (ROI-i) method through 2 statistical approaches (ANOVA and Pearson's R).
First, whole-brain analyses performed on modulated data are as sensitive as the ROI-i approach in detecting aMCI patients' hippocampal atrophy. Second, values extracted from the ROI-template applied to modulated data provide measures of hippocampal volume comparable to those obtained using the ROI-i approach.
This study provides guidance on how to extract accurate hippocampal measures from VBM-derived data in early AD, as a time-saving and easy alternative to the reference ROI-i method.
为评估早期阿尔茨海默病（AD）中海马萎缩，提供关于最合适的基于体素形态计量学（VBM）方法的指导。
在 23 名有遗忘型轻度认知障碍（aMCI）的患者和 18 名对照中收集 T1-MRI 容积数据。比较了 3 种类型的数据（未调制和 2 种调制 MRI）和 2 种提取方法（参考从全脑初步分析中确定的海马萎缩峰值，或使用模板感兴趣区-ROI-方法）与金标准个体 ROI（ROI-i）方法，通过 2 种统计方法（ANOVA 和 Pearson 的 R）。
首先，在调制数据上进行的全脑分析在检测 aMCI 患者的海马萎缩方面与 ROI-i 方法一样敏感。其次，应用于调制数据的 ROI 模板中提取的值提供了与 ROI-i 方法获得的海马体积测量值相当的指标。
这项研究提供了如何从早期 AD 的 VBM 衍生数据中提取准确的海马测量值的指导，作为参考 ROI-i 方法的省时省力的替代方法。
