Mucosal Immunology Section, OIIB, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Semin Immunol. 2011 Dec;23(6):418-23. doi: 10.1016/j.smim.2011.06.005. Epub 2011 Jul 12.
Induction of Foxp3 gene expression and acquisition of regulatory T cell fate is, understandably, a highly controlled process and one which many investigators want to illuminate. In studying the regulation of Foxp3 gene expression, several conserved non-coding regions have been identified and the role of various transcription factors at these sites has been explored. What emerges is that many factors, some positive, some negative, interact to collectively drive Foxp3 gene expression and then maintain its expression in Foxp3(+) regulatory T cells. TCR signaling is imperative for Foxp3 gene expression and TGF-β is a key cytokine for initiating Foxp3 gene expression in naïve T cells. But other signaling pathways are also known to play a role in properly orchestrating Foxp3 gene expression and regulatory T cell expansion. Here we review the recent progress in understanding the complex molecular events that drive Foxp3 gene expression and allow functional regulatory T cells to develop.
Foxp3 基因表达的诱导和调节性 T 细胞命运的获得是一个高度受控的过程，许多研究人员都希望对此加以阐明。在研究 Foxp3 基因表达的调控过程中，已经鉴定出几个保守的非编码区域，并探讨了各种转录因子在这些位点的作用。结果表明，许多因素（有些是正调控，有些是负调控）相互作用，共同驱动 Foxp3 基因表达，并在 Foxp3(+)调节性 T 细胞中维持其表达。TCR 信号对于 Foxp3 基因表达是必不可少的，TGF-β是在初始 T 细胞中启动 Foxp3 基因表达的关键细胞因子。但也有其他信号通路被认为在正确协调 Foxp3 基因表达和调节性 T 细胞扩增中发挥作用。本文综述了在理解驱动 Foxp3 基因表达和使功能性调节性 T 细胞发育的复杂分子事件方面的最新进展。
