丙型肝炎病毒感染被病毒感染细胞释放的高迁移率族蛋白 B1 所阻断。
Hepatitis C virus infection is blocked by HMGB1 released from virus-infected cells.
机构信息
PBC, Department of Life Science, Pohang University of Science and Technology, San 31, Hyoja-Dong, Pohang 790-784, Republic of Korea.
出版信息
J Virol. 2011 Sep;85(18):9359-68. doi: 10.1128/JVI.00682-11. Epub 2011 Jul 13.
Abstract
High-mobility group box 1 (HMGB1), an abundant nuclear protein that triggers host immune responses, is an endogenous danger signal involved in the pathogenesis of various infectious agents. However, its role in hepatitis C virus (HCV) infection is not known. Here, we show that HMGB1 protein is translocated from the nucleus to cytoplasm and subsequently is released into the extracellular milieu by HCV infection. Secreted HMGB1 triggers antiviral responses and blocks HCV infection, a mechanism that may limit HCV propagation in HCV patients. Secreted HMGB1 also may have a role in liver cirrhosis, which is a common comorbidity in HCV patients. Further investigations into the roles of HMGB1 in the diseases caused by HCV infection will shed light on and potentially help prevent these serious and prevalent HCV-related diseases.
摘要
高迁移率族蛋白 B1（HMGB1）是一种丰富的核蛋白，可触发宿主免疫反应，是参与各种感染因子发病机制的内源性危险信号。然而，其在丙型肝炎病毒（HCV）感染中的作用尚不清楚。在这里，我们表明 HCV 感染可导致 HMGB1 蛋白从核内转移到细胞质，并随后被释放到细胞外环境中。分泌的 HMGB1 可触发抗病毒反应并阻断 HCV 感染，这一机制可能限制了 HCV 患者中的 HCV 增殖。分泌的 HMGB1 也可能在 HCV 患者常见的肝硬化中发挥作用。进一步研究 HMGB1 在 HCV 感染引起的疾病中的作用，将有助于阐明和预防这些严重且普遍存在的 HCV 相关疾病。
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