Dominguez Iglesias F, Fresno Forcelledo F, Soler Sanchez T, Fernandez García L, Herrero Zapatero A
Department of Pathology, Hospital Nuestra Señora de Covadonga, Oviedo, Spain.
Histopathology. 1990 Oct;17(4):311-7. doi: 10.1111/j.1365-2559.1990.tb00734.x.
Fifteen cases of chondroid syringoma have been studied histologically and by immunohistochemical methods in an attempt to establish their phenotypic profile and to elucidate their histogenesis. The epithelial elements were classified as tubuloglandular, solid nests and stromal cells. The inner cell layers of tubuloglandular components had distinct epithelial features, expressing cytokeratin, carcino-embryonic antigen and epithelial membrane antigen. The outer cell layers expressed vimentin, S-100 protein, neuron-specific enolase and muscle-specific actin and were negative for epithelial markers. The immunophenotypes of stromal cells and solid nests were similar to those of the outer cell layers. These data suggest that the stromal components may derive from the outer cell of tubuloglandular elements and that myo-epithelial cells have an important role in the histogenesis of these lesions and in their mesenchymal matrix production.
对15例软骨样汗腺腺瘤进行了组织学和免疫组化研究，以确定其表型特征并阐明其组织发生。上皮成分分为管状腺、实性巢和基质细胞。管状腺成分的内层细胞具有明显的上皮特征，表达细胞角蛋白、癌胚抗原和上皮膜抗原。外层细胞表达波形蛋白、S-100蛋白、神经元特异性烯醇化酶和肌肉特异性肌动蛋白，上皮标志物呈阴性。基质细胞和实性巢的免疫表型与外层细胞相似。这些数据表明，基质成分可能来源于管状腺成分的外层细胞，肌上皮细胞在这些病变的组织发生及其间充质基质产生中起重要作用。
