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用杆状病毒表面展示的甲型H1N1流感大流行病毒血凝素进行皮下免疫可诱导小鼠产生保护性免疫。

Subcutaneous immunization with baculovirus surface-displayed hemagglutinin of pandemic H1N1 Influenza A virus induces protective immunity in mice.

作者信息

Prabakaran Mookkan, Meng Tao, He Fang, Yunrui Tan, Qiang Jia, Lin Raymond Tzer Pin, Kwang Jimmy

机构信息

Animal Health Biotechnology, Temasek Life Sciences Laboratory, National University of Singapore, Singapore 117604, Singapore.

出版信息

Clin Vaccine Immunol. 2011 Sep;18(9):1582-5. doi: 10.1128/CVI.05114-11. Epub 2011 Jul 13.

DOI:10.1128/CVI.05114-11
PMID:21752948
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3165240/
Abstract

The protective immunity of baculovirus displaying influenza virus hemagglutinin (BacHA) against influenza 2009 H1N1 virus infection in a murine model was investigated. The results showed that mice vaccinated with live BacHA or an inactive form of adjuvanted BacHA had enhanced specific antibody responses and induced protective immunity against 2009 H1N1 virus infection, suggesting the potential of baculovirus as a live or inactivated vaccine.

摘要

研究了在小鼠模型中，展示流感病毒血凝素的杆状病毒（BacHA）对2009年甲型H1N1流感病毒感染的保护性免疫。结果表明，接种活的BacHA或佐剂化的灭活BacHA的小鼠具有增强的特异性抗体反应，并诱导了针对2009年甲型H1N1流感病毒感染的保护性免疫，这表明杆状病毒作为活疫苗或灭活疫苗的潜力。

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本文引用的文献

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Baculovirus as vaccine vectors.杆状病毒作为疫苗载体。
Curr Gene Ther. 2010 Jun;10(3):201-13. doi: 10.2174/156652310791321233.
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Safety of influenza vaccine administration in egg-allergic patients.鸡蛋过敏患者接种流感疫苗的安全性。
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Gastrointestinal delivery of baculovirus displaying influenza virus hemagglutinin protects mice against heterologous H5N1 infection.杆状病毒展示的流感病毒血凝素经胃肠道传递可保护小鼠免受异源 H5N1 感染。
J Virol. 2010 Apr;84(7):3201-9. doi: 10.1128/JVI.02175-09. Epub 2010 Jan 13.
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