在年轻男性成年人中，IgA 缺乏与呼吸道变应性之间不存在关联。

Lack of association between IgA deficiency and respiratory atopy in young male adults.

机构信息

Department of Infectious Diseases, Hospital "Dei Colli", 80131 Naples, Italy.

出版信息

In Vivo. 2011 Sep-Oct;25(5):829-32.

Abstract

BACKGROUND

The issue of atopy and increased serum IgE in IgA deficiency is still a matter of debate. The aim of this study was to evaluate the prevalence of IgA deficiency and its relationship with respiratory atopy.

MATERIALS AND METHODS

A retrospective study on 4700 consecutive young males (age range 18-23), who underwent a health screen for admission to the Italian Airforce Academy between 1993 and 1995 was conducted. Serum IgA was measured by immunoturbidimetry and total and specific IgE by fluorescent enzyme immunoassay (Phadiatop FEIA, Pharmacia Cap System). Airway responsiveness was assessed by methacholine challenge.

RESULTS

IgA deficiency was detected in 0.34% (16/4700) subjects and atopy was detected in 8.6% (406/4700). The mean IgA was 243 mg/dl (95% CI 107, 442) in the 406 atopic subjects and 238 mg/dl (95% CI 100, 441) in 1544 controls. Only 6 (37.5%) of the IgA deficient subjects had subnormal IgE levels and 6 were positive in the fluorescent EIA. None of the IgA deficient patients presented with respiratory hyper-reactivity.

CONCLUSION

Atopy is not more prevalent in young male adult IgA deficient subjects, who rather display a high frequency of recurrent sinusitis.

摘要

背景

关于 IgA 缺乏症和血清 IgE 升高的特应性问题仍存在争议。本研究旨在评估 IgA 缺乏症的患病率及其与呼吸道特应性的关系。

材料和方法

对 1993 年至 1995 年间参加意大利空军学院入伍体检的 4700 名连续年轻男性（年龄范围 18-23 岁）进行了回顾性研究。采用免疫比浊法检测血清 IgA，采用荧光酶免疫分析法（Phadiatop FEIA，Pharmacia Cap System）检测总 IgE 和特异性 IgE。采用乙酰甲胆碱激发试验评估气道反应性。

结果

在 4700 名受试者中，检出 0.34%（16/4700）的 IgA 缺乏症，8.6%（406/4700）的受试者存在特应性。在 406 名特应性受试者中，平均 IgA 为 243mg/dl（95%CI 107，442），在 1544 名对照者中，平均 IgA 为 238mg/dl（95%CI 100，441）。仅 6 名（37.5%）IgA 缺乏症患者的 IgE 水平低于正常，6 名患者的荧光 EIA 呈阳性。IgA 缺乏症患者均未出现呼吸高反应性。