[有症状的IgA缺乏症患者的IgG亚类]
[IgG subclasses in patients with symptomatic IgA deficiency].
作者信息
de Gracia J, Miravitlles M, Vendrell M, Ròdrigo M J, Codina R, Morell F
机构信息
Servicio de Neumología, Hospital General Universitari Vall d'Hebron, Barcelona.
出版信息
Med Clin (Barc). 1995 May 20;104(19):728-31.
BACKGROUND
Patients with IgA deficiency may be asymptomatic or may present recurrent infections mainly respiratory. A possible explanation for this variety of symptoms may be the association with a deficiency of IgG subclasses.
METHODS
Twenty-five patients with a symptomatic IgA deficiency with a mean age of 18 +/- 12 years were studied. The quantification of the IgG subclasses was performed by ELISA test with antisubclass specific monoclonal murine antibodies. Serum from 100 healthy adults was collected to determine normal values of the IgG subclasses.
RESULTS
Twenty-five (48%) had a deficiency of associated IgG subclasses (6 IgG2 deficiency, 1 IgG3, 3 IgG4 and 2 combined deficiency). The patient with a deficiency of associated IgG subclasses had more recurrent respiratory infections (chi 2, p < 0.03) and pneumonias (chi 2, p < 0.04). This group also had a greater FEV1 alteration (Student-t test, p < 0.04).
CONCLUSIONS
Patients with symptomatic IgA deficiency frequently present IgG subclass deficiency and are more likely to have recurrent respiratory infections and greater changes in pulmonary function.
背景
IgA 缺乏症患者可能无症状，或主要表现为反复发生呼吸道感染。对于这种多样症状的一种可能解释是与 IgG 亚类缺乏相关。
方法
研究了 25 例有症状的 IgA 缺乏症患者，平均年龄为 18±12 岁。采用抗亚类特异性单克隆鼠抗体的 ELISA 试验对 IgG 亚类进行定量。收集 100 名健康成年人的血清以确定 IgG 亚类的正常值。
结果
25 例（48%）存在相关 IgG 亚类缺乏（6 例 IgG2 缺乏，1 例 IgG3 缺乏，3 例 IgG4 缺乏，2 例联合缺乏）。存在相关 IgG 亚类缺乏的患者有更多的反复呼吸道感染（卡方检验，p<0.03）和肺炎（卡方检验，p<0.04）。该组患者的第一秒用力呼气容积（FEV1）改变也更大（学生 t 检验，p<0.04）。
结论
有症状的 IgA 缺乏症患者常存在 IgG 亚类缺乏，更易发生反复呼吸道感染且肺功能改变更大。
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