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4,5-双（4-氟苯基）-5-羟基-3-（2-甲基丙酰基）-1-苯基吡咯烷-2-酮

4,5-Bis(4-fluoro-phen-yl)-5-hy-droxy-3-(2-methyl-propano-yl)-1-phenyl-pyrrolidin-2-one.

作者信息

Huang Jian-Ying, Zhou Fengyan

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 1;67(Pt 4):o873-4. doi: 10.1107/S1600536811008786. Epub 2011 Mar 12.

DOI:10.1107/S1600536811008786
PMID:21754151
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3099992/
Abstract

The title compound, C(26)H(23)F(2)NO(3), was synthesized by the reaction of 2-(4-fluoro-benzyl-idene)-4-methyl-3-oxo-N-phenyl-penta-namide and 4-fluoro-benzaldehyde. The dihedral angles between the mean plane through the pyrrolidine ring (nearly planar; maximum deviation of 0.145 Å for the C atom bearing the hydroxy group) with the phenyl and benzene rings are 37.22 (7), 51.88 (7) and 87.64 (9)°, respectively. The pyyolidine ring is near coplaner, with max offset of 0.145 A for C19 atom.\uff09 In the crystal, mol-ecules are linked by pairs of O-H⋯O hydrogen bonds into inversion dimers, which are further assembled into chains parallel to the b axis by weak C-H⋯O hydrogen bonds.

摘要

标题化合物C(26)H(23)F(2)NO(3)是由2-(4-氟亚苄基)-4-甲基-3-氧代-N-苯基戊酰胺与4-氟苯甲醛反应合成的。通过吡咯烷环的平均平面（几乎为平面；带有羟基的C原子的最大偏差为0.145 Å）与苯环和苯基环之间的二面角分别为37.22 (7)°、51.88 (7)°和87.64 (9)°。吡咯烷环接近共面，C19原子的最大偏移为0.145 Å。在晶体中，分子通过O-H⋯O氢键对连接成反演二聚体，这些二聚体通过弱C-H⋯O氢键进一步组装成平行于b轴的链。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b12d/3099992/62eb9282b52b/e-67-0o873-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b12d/3099992/62eb9282b52b/e-67-0o873-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b12d/3099992/62eb9282b52b/e-67-0o873-fig1.jpg

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本文引用的文献

1
A short history of SHELX.SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
2
Atorvastatin. A review of its pharmacology and therapeutic potential in the management of hyperlipidaemias.阿托伐他汀。其在高脂血症管理中的药理学及治疗潜力综述。
Drugs. 1997 May;53(5):828-47. doi: 10.2165/00003495-199753050-00011.