• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

（2Z，4E）-1-（5-氟-2-羟基苯基）-5-（4-氟苯基）-3-羟基戊-2，4-二烯-1-酮

(2Z,4E)-1-(5-Fluoro-2-hy-droxy-phen-yl)-5-(4-fluoro-phen-yl)-3-hy-droxy-penta-2,4-dien-1-one.

作者信息

Chen Jing-Wei, He Zhuo, Wu Zhen, Fang Mei-Juan, Fang Hua

机构信息

The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen 361005, People's Republic of China.

School of Pharmaceutical Sciences, Xiamen University, Sounth Xiang-An Road, Xiamen 361100, People's Republic of China.

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2013 Dec 24;70(Pt 1):o88. doi: 10.1107/S1600536813033564. eCollection 2014 Jan 1.

DOI:10.1107/S1600536813033564
PMID:24527017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3914111/
Abstract

In the title mol-ecule, C17H12F2O3, the dihedral angle between the benzene rings is 8.6 (2)°. In the crystal, two pairs of O-H⋯O hydrogen bonds connect the mol-ecules into inversion dimers. In addition, weak C-H⋯F hydrogen bonds link the dimers into a two-dimensional network parallel to (10-4). The carbonyl O atom is an acceptor for two weak intra-molecular hydrogen bonds.

摘要

在标题分子C₁₇H₁₂F₂O₃中，苯环之间的二面角为8.6 (2)°。在晶体中，两对O—H⋯O氢键将分子连接成反演二聚体。此外，弱C—H⋯F氢键将二聚体连接成平行于(10-4)的二维网络。羰基O原子是两个弱分子内氢键的受体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/099d/3914111/25d5955397cf/e-70-00o88-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/099d/3914111/ed551ea4097c/e-70-00o88-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/099d/3914111/85b0f59c9c15/e-70-00o88-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/099d/3914111/ed61be36f6ef/e-70-00o88-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/099d/3914111/25d5955397cf/e-70-00o88-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/099d/3914111/ed551ea4097c/e-70-00o88-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/099d/3914111/85b0f59c9c15/e-70-00o88-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/099d/3914111/ed61be36f6ef/e-70-00o88-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/099d/3914111/25d5955397cf/e-70-00o88-fig4.jpg

相似文献

1
(2Z,4E)-1-(5-Fluoro-2-hy-droxy-phen-yl)-5-(4-fluoro-phen-yl)-3-hy-droxy-penta-2,4-dien-1-one.（2Z，4E）-1-（5-氟-2-羟基苯基）-5-（4-氟苯基）-3-羟基戊-2，4-二烯-1-酮
Acta Crystallogr Sect E Struct Rep Online. 2013 Dec 24;70(Pt 1):o88. doi: 10.1107/S1600536813033564. eCollection 2014 Jan 1.
2
(2Z)-3-(4-Fluoro-anilino)-1-(5-hy-droxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)but-2-en-1-one.（2Z）-3-（4-氟苯胺基）-1-（5-羟基-3-甲基-1-苯基-1H-吡唑-4-基）丁-2-烯-1-酮
Acta Crystallogr Sect E Struct Rep Online. 2012 Mar 1;68(Pt 3):o764. doi: 10.1107/S1600536812006514. Epub 2012 Feb 17.
3
()-1-(4-Fluoro-2-hy-droxy-phen-yl)-3-(2,3,4-tri-meth-oxy-phen-yl)prop-2-en-1-one.（）-1-（4-氟-2-羟基苯基）-3-（2,3,4-三甲氧基苯基）丙-2-烯-1-酮。
IUCrdata. 2020 Jan 24;5(Pt 1):x200071. doi: 10.1107/S2414314620000711. eCollection 2020 Jan.
4
(2Z)-3-(2,4-Di-chloro-phen-yl)-3-hy-droxy-N-phenyl-prop-2-ene-thio-amide.（2Z）-3-（2,4-二氯苯基）-3-羟基-N-苯基丙-2-烯硫代酰胺
Acta Crystallogr Sect E Struct Rep Online. 2013 Jun 29;69(Pt 7):o1173-4. doi: 10.1107/S1600536813017339. eCollection 2013.
5
3-(4-Fluoro-benzo-yl)-4-(4-fluoro-phen-yl)-4-hy-droxy-2,6-di-phenyl-cyclo-hexane-1,1-dicarbo-nitrile.3-（4-氟-苯甲酰基）-4-（4-氟-苯基）-4-羟基-2,6-二苯基-环己烷-1,1-二甲腈
Acta Crystallogr Sect E Struct Rep Online. 2014 May 31;70(Pt 6):o736-7. doi: 10.1107/S1600536814012197. eCollection 2014 Jun 1.
6
4,5-Bis(4-fluoro-phen-yl)-5-hy-droxy-3-(2-methyl-propano-yl)-1-phenyl-pyrrolidin-2-one.4,5-双（4-氟苯基）-5-羟基-3-（2-甲基丙酰基）-1-苯基吡咯烷-2-酮
Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 1;67(Pt 4):o873-4. doi: 10.1107/S1600536811008786. Epub 2011 Mar 12.
7
1-[3-(2-Benz-yloxy-6-hy-droxy-4-methyl-phen-yl)-5-[3,5-bis-(tri-fluoro-meth-yl)phen-yl]-4,5-di-hydro-1H-pyrazol-1-yl]propane-1-one.1-[3-(2-苄氧基-6-羟基-4-甲基苯基)-5-[3,5-双(三氟甲基)苯基]-4,5-二氢-1H-吡唑-1-基]丙烷-1-酮
Acta Crystallogr Sect E Struct Rep Online. 2013 May 4;69(Pt 6):o840. doi: 10.1107/S160053681301180X. Print 2013 Jun 1.
8
4-{(4Z)-4-[(2Z)-3-(4-Fluoro-anilino)-1-hy-droxy-but-2-en-1-yl-idene]-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl}-benzene-sulfonamide.4-{（4Z）-4-[(2Z)-3-(4-氟苯胺基)-1-羟基丁-2-烯-1-亚基]-3-甲基-5-氧代-4,5-二氢-1H-吡唑-1-基}-苯磺酰胺
Acta Crystallogr Sect E Struct Rep Online. 2012 Mar 1;68(Pt 3):o762-3. doi: 10.1107/S1600536812006502. Epub 2012 Feb 17.
9
(E)-4-Hy-droxy-2-[(2-hy-droxy-phen-yl)iminiometh-yl]phenolate.（E）-4-羟基-2-[(2-羟基苯基)亚氨基甲基]苯酚盐
Acta Crystallogr Sect E Struct Rep Online. 2010 Jun 5;66(Pt 7):o1536-7. doi: 10.1107/S1600536810020295.
10
(E)-1-(2,4-Dihy-droxy-phen-yl)-3-(4-hydroxy-phen-yl)prop-2-en-1-one monohydrate.（E）-1-（2,4-二羟基苯基）-3-（4-羟基苯基）丙-2-烯-1-酮一水合物
Acta Crystallogr Sect E Struct Rep Online. 2011 Feb 26;67(Pt 3):o732. doi: 10.1107/S1600536811006271.

本文引用的文献

1
(2E)-3-(2-Fluoro-phen-yl)-1-(4-fluoro-phen-yl)prop-2-en-1-one.（2E）-3-（2-氟苯基）-1-（4-氟苯基）丙-2-烯-1-酮
Acta Crystallogr Sect E Struct Rep Online. 2012 Sep 1;68(Pt 9):o2658. doi: 10.1107/S1600536812034411. Epub 2012 Aug 8.
2
Structure validation in chemical crystallography.化学晶体学中的结构验证
Acta Crystallogr D Biol Crystallogr. 2009 Feb;65(Pt 2):148-55. doi: 10.1107/S090744490804362X. Epub 2009 Jan 20.
3
Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
一种柯里拉京A-4类似查耳酮的铂（II）配合物：共轭对细胞毒性、肿瘤特异性和长期肿瘤生长抑制的影响。
J Med Chem. 2009 Jan 22;52(2):241-6. doi: 10.1021/jm801001d.
4
A short history of SHELX.SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
5
Carboxylated, heteroaryl-substituted chalcones as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases.羧化的、杂芳基取代的查耳酮作为血管细胞粘附分子-1表达抑制剂用于慢性炎症性疾病。
J Med Chem. 2007 Mar 22;50(6):1304-15. doi: 10.1021/jm0614230. Epub 2007 Feb 27.