神经肽Y抑制肾近端曲管中cAMP的积累。
Neuropeptide Y inhibits cAMP accumulation in renal proximal convoluted tubules.
作者信息
Edwards R M
机构信息
Department of Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406-0939.
出版信息
Regul Pept. 1990 Oct 8;30(3):201-6. doi: 10.1016/0167-0115(90)90095-e.
The effect of neuropeptide Y (NPY) on cAMP accumulation in various segments of the rabbit nephron was examined. NPY inhibited parathyroid hormone-stimulated cAMP accumulation in the proximal convoluted tubule in a concentration-dependent manner. NPY also inhibited forskolin-stimulated cAMP production in this segment of the nephron. In contrast, NPY had no effect on parathyroid hormone or forskolin-stimulated cAMP accumulation in the proximal straight tubule. Similarly, NPY had no effect on forskolin-stimulated cAMP levels along the rest of the nephron. These results are consistent with previous studies which have localized NPY receptors to the proximal convoluted tubule, and suggest that NPY via its effects on cAMP metabolism may play a role in proximal tubule transport.
研究了神经肽Y（NPY）对兔肾单位各节段中环磷酸腺苷（cAMP）积累的影响。NPY以浓度依赖的方式抑制甲状旁腺激素刺激的近端曲管中cAMP的积累。NPY还抑制该肾单位节段中福斯高林刺激的cAMP产生。相比之下，NPY对近端直小管中甲状旁腺激素或福斯高林刺激的cAMP积累没有影响。同样，NPY对肾单位其余部分福斯高林刺激的cAMP水平也没有影响。这些结果与先前将NPY受体定位于近端曲管的研究一致，并表明NPY通过其对cAMP代谢的影响可能在近端小管转运中发挥作用。
Zotero 插件