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Febuxostat methanol solvate.

作者信息

Jiang Qi-Ying, Qian Jing-Jing, Gu Jian-Ming, Tang Gu-Ping, Hu Xiu-Rong

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2011 May 1;67(Pt 5):o1232. doi: 10.1107/S1600536811014905. Epub 2011 Apr 29.

Abstract

In the title compound {systematic name: [2-(3-cyano-4-isobutyl-oxyphen-yl)-4-methyl-1,3-thia-zole-5-carb-oxy-lic acid (febuxostat) methanol monosolvate}, C(16)H(16)N(2)O(3)S·CH(4)O, the benzene and thia-zole rings in the febuxostat mol-ecule are twisted at 5.3 (1)°. In the crystal structure, inter-molecular O-H⋯O and O-H⋯N hydrogen bonds link the febuxostat and methanol mol-ecules into helical chains along the 2(1) screw axis.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f639/3089318/454e8cf4993e/e-67-o1232-fig1.jpg

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