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4-羟基-3,5-二甲氧基-N-{4-[(5-甲基-1,2-恶唑-3-基)氨磺酰基]苯基}苯甲酰胺甲醇单溶剂合物

4-Hy-droxy-3,5-dimeth-oxy-N-{4-[(5-methyl-1,2-oxazol-3-yl)sulfamo-yl]phen-yl}benzamide methanol monosolvate.

作者信息

Pan Wei-Gao, Zhao Zhi-Dong, Luo Peng, Lin Cui-Wu, Miao Jian-Hua

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2012 Feb 1;68(Pt 2):o379. doi: 10.1107/S1600536811055991. Epub 2012 Jan 14.

DOI:10.1107/S1600536811055991
PMID:22347002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3275057/
Abstract

The title compound, C(19)H(19)N(3)O(7)S·CH(3)OH, was synthesized from syringic acid and sulfamethoxazole. The benzene rings make a dihedral angle of 41.8 (1)° and the isoxazole ring is twisted by 74.3 (1)° from the central benzene ring. The crystal packing features O-H⋯O and O-H⋯N hydrogen bonds in which the hy-droxy groups from the main mol-ecule and methanol solvent mol-ecules serve as donor groups.

摘要

标题化合物C(19)H(19)N(3)O(7)S·CH(3)OH由丁香酸和磺胺甲恶唑合成。苯环间的二面角为41.8 (1)°，异恶唑环与中心苯环扭转74.3 (1)°。晶体堆积具有O-H⋯O和O-H⋯N氢键，其中主分子和甲醇溶剂分子中的羟基作为供体基团。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a260/3275057/8a6b4579b93c/e-68-0o379-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a260/3275057/03937204c117/e-68-0o379-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a260/3275057/c26edf624618/e-68-0o379-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a260/3275057/8a6b4579b93c/e-68-0o379-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a260/3275057/03937204c117/e-68-0o379-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a260/3275057/c26edf624618/e-68-0o379-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a260/3275057/8a6b4579b93c/e-68-0o379-fig3.jpg

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本文引用的文献

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