Huarcaya Erick, Best Ivan, Rodriguez-Tafur Juan, Maguiña Ciro, Solórzano Nelson, Menacho Julio, Lopez De Guimaraes Douglas, Chauca Jose, Ventosilla Palmira
Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru.
Rev Inst Med Trop Sao Paulo. 2011 May-Jun;53(3):149-54. doi: 10.1590/s0036-46652011000300006.
Human Bartonellosis has an acute phase characterized by fever and hemolytic anemia, and a chronic phase with bacillary angiomatosis-like lesions. This cross-sectional pilot study evaluated the immunology patterns using pre- and post-treatment samples in patients with Human Bartonellosis. Patients between five and 60 years of age, from endemic areas in Peru, in the acute or chronic phases were included. In patients in the acute phase of Bartonellosis a state of immune peripheral tolerance should be established for persistence of the infection. Our findings were that elevation of the anti-inflammatory cytokine IL-10 and numeric abnormalities of CD4(+) and CD8(+) T-Lymphocyte counts correlated significantly with an unfavorable immune state. During the chronic phase, the elevated levels of IFN-γ and IL-4 observed in our series correlated with previous findings of endothelial invasion of B. henselae in animal models.
人类巴尔通体病有一个以发热和溶血性贫血为特征的急性期，以及一个伴有杆菌性血管瘤样病变的慢性期。这项横断面试点研究使用人类巴尔通体病患者治疗前和治疗后的样本评估了免疫模式。纳入了来自秘鲁流行地区、年龄在5至60岁之间、处于急性期或慢性期的患者。在巴尔通体病急性期的患者中，为使感染持续存在应建立免疫外周耐受状态。我们的研究结果是，抗炎细胞因子IL-10的升高以及CD4(+)和CD8(+) T淋巴细胞计数的数值异常与不良免疫状态显著相关。在慢性期，我们系列研究中观察到的IFN-γ和IL-4水平升高与动物模型中先前发现的亨氏巴尔通体的内皮侵袭相关。
