Hansen T R, Henkes L K, Ashley R L, Bott R C, Antoniazzi A Q, Han H
Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, Centro de Ciências Rurais, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil.
Soc Reprod Fertil Suppl. 2010;67:325-40. doi: 10.7313/upo9781907284991.026.
The ovine conceptus releases interferon-tau (IFNT), which prevents upregulation of the endometrial estrogen receptor (ESR1) and, consequently, oxytocin receptor (OXTR), thereby disrupting pulsatile release of prostaglandin F2alpha (PGF) in response to oxytocin. IFNT, through paracrine action on the endometrium, protects the corpus luteum (CL) during maternal recognition of pregnancy. Pregnancy also induces IFN stimulated genes (ISGs) in peripheral blood mononuclear cells (PBMCs), which is interpreted to reflect a "prompted" antiviral and immune cell response peripherally in ruminants. IFNT was recently demonstrated to be released from the uterus in amounts of 200 microg (2 x 10(7) U)/24 h via the uterine vein and to induce ISGs in the CL during maternal recognition of pregnancy. Delivery of recombinant ovine (ro) IFNT into the uterine vein in a location that is upstream of the utero-ovarian plexus from Day 10 to 17 maintained serum progesterone concentrations and extended normal 16-17 d estrous cycles to beyond 32 d. It is concluded from these studies that IFNT is released into the uterine vein and initiates a peripheral antiviral response to protect pregnancy from maternal viral infection. It also may have endocrine action through inducing luteal resistance to PGF and longer-term survival of the CL and maintenance of pregnancy.
绵羊孕体释放干扰素-τ（IFNT），它可防止子宫内膜雌激素受体（ESR1）上调，进而防止催产素受体（OXTR）上调，从而破坏对催产素作出反应的前列腺素F2α（PGF）的脉冲式释放。IFNT通过对子宫内膜的旁分泌作用，在母体识别妊娠期间保护黄体（CL）。妊娠还会诱导外周血单核细胞（PBMC）中的干扰素刺激基因（ISG），这被认为反映了反刍动物外周的“激发”抗病毒和免疫细胞反应。最近证明，IFNT以200微克（2×10⁷单位）/24小时的量通过子宫静脉从子宫释放，并在母体识别妊娠期间诱导黄体中的ISG。从第10天到第17天，将重组绵羊（ro）IFNT输送到子宫卵巢丛上游位置的子宫静脉中，可维持血清孕酮浓度，并将正常的16 - 17天发情周期延长至32天以上。从这些研究得出的结论是，IFNT释放到子宫静脉中，并引发外周抗病毒反应，以保护妊娠免受母体病毒感染。它还可能通过诱导黄体对PGF产生抗性以及延长黄体的长期存活和维持妊娠而具有内分泌作用。
