Cosmetic and Natural Product Research Center, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand.
J Dermatolog Treat. 2012 Oct;23(5):385-92. doi: 10.3109/09546634.2011.568470. Epub 2011 Jul 14.
Several botanically derived agents are available for the treatment of male-pattern baldness.
The aim of this study was to evaluate the efficacy of 5% hexane extract of Curcuma aeruginosa, a botanically derived inhibitor of 5α-reductase and 5% minoxidil in the treatment of androgenetic alopecia.
Eighty-seven men with androgenetic alopecia (AGA) were randomized to receive 5% Curcuma aeruginosa, 5% minoxidil, combination formulation (5% hexane extract of Curcuma aeruginosa + 5% minoxidil) or placebo, twice daily for 6 months. Efficacy was assessed by target area hair count, global photographic review as well as patients' subjective assessments of hair regrowth and hair shedding.
There were statistically significant improvements in global photographic review (p < 0.001), subjects' overall assessments of hair regrowth (p = 0.008), and hair shedding (p = 0.004) when the combination formulation was compared with placebo. Similarly, treatment with 5% minoxidil and 5% C. aeruginosa extract also led to some degrees of hair regrowth. There were no serious adverse events during and after the study.
In men with hair loss in the vertex area of the scalp, the combination of 5% hexane extract of C. aeruginosa and 5% minoxidil slowed hair loss and increased hair growth.
有几种植物衍生剂可用于治疗男性型秃发。
本研究旨在评估 5%莪术己烷提取物（一种植物源性 5α-还原酶抑制剂）和 5%米诺地尔治疗雄激素性脱发的疗效。
87 例男性雄激素性脱发患者随机分为 5%莪术、5%米诺地尔、联合制剂（5%莪术己烷提取物+5%米诺地尔）或安慰剂组，每天两次，疗程 6 个月。通过靶区毛发计数、全球照片评估以及患者对头发再生和脱发的主观评估来评估疗效。
与安慰剂相比，联合制剂在全球照片评估（p<0.001）、患者对头发再生的总体评估（p=0.008）和脱发（p=0.004）方面均有统计学显著改善。同样，5%米诺地尔和 5%莪术提取物的治疗也导致了一定程度的头发再生。研究期间和研究结束后均无严重不良事件。
在头皮顶点脱发的男性中，5%莪术己烷提取物和 5%米诺地尔的联合应用可减缓脱发并促进头发生长。
