University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Dev Psychopathol. 2011 Aug;23(3):897-906. doi: 10.1017/S0954579411000381.
Research shows that poor social ties increase risks of morbidity and mortality from cardiovascular disease (CVD). However, little is known about the nature of everyday social encounters that give rise to this association, or when in the course of development they begin to shape disease-relevant biological processes. In this study, 122 adolescent females recorded the qualities of their everyday social interactions using electronic diaries. At the same time we measured components of the metabolic syndrome, a precursor to CVD that includes central adiposity, high blood pressure, insulin resistance, and lipid dysregulation. Metabolic symptoms were reassessed 12 and 24 months later. Hierarchical linear modeling revealed an association between negative social interactions and metabolic symptom trajectories. To the extent that participants had more intense negative social encounters in daily life, they showed increasing scores on a composite indicator of metabolic risk over 2 years. This association was independent of a variety of potential confounders, and persisted when symptoms of depression and broader personality traits were controlled. There was no association between positive social encounters and metabolic risk trajectories. These findings suggest that even in otherwise healthy adolescents, abrasive social encounters may accelerate the progression of early stages of CVD.
研究表明，较差的社会关系会增加心血管疾病（CVD）发病率和死亡率的风险。然而，人们对于导致这种关联的日常社会交往的性质，以及它们在发展过程中何时开始影响与疾病相关的生物过程，知之甚少。在这项研究中，122 名青春期女性使用电子日记记录了她们日常社交互动的质量。与此同时，我们测量了代谢综合征的成分，这是 CVD 的前兆，包括中心性肥胖、高血压、胰岛素抵抗和脂质失调。代谢症状在 12 个月和 24 个月后重新评估。分层线性模型显示，负面社会互动与代谢症状轨迹之间存在关联。在日常生活中，参与者经历更强烈的负面社交事件的程度，他们在 2 年内的代谢风险综合指标上的得分会逐渐增加。这种关联独立于多种潜在的混杂因素，且在控制抑郁症状和更广泛的人格特征后仍然存在。积极的社会交往与代谢风险轨迹之间没有关联。这些发现表明，即使在其他方面健康的青少年中，摩擦性的社交接触也可能加速 CVD 早期阶段的进展。
