Intensive Care Unit, Department of Surgery, University of Pisa, Pisa, Italy.
Nutr Neurosci. 2011 May;14(3):119-25. doi: 10.1179/1476830511Y.0000000007.
The aim of this work was to highlight the effects and the possible mechanisms of the action of blueberry polyphenols on the central nervous system (CNS).
An analysis was carried out, in a temporal order, of the most important literature about this topic and the results have been correlated with the beneficial and protective effects, mainly concerning the CNS.
Over the last 10 years an increasing scientific interest has developed about polyphenols, which are very abundant in blueberries, as they have been seen to produce favourable effects related to neuroprotection and linked to a possible decrease of age-related cognitive and motor decline, as shown by the improvement of such functions in animal models with a supplemented diet. Such effects could not only be explained through a purely antioxidant action but also through more complex mechanisms related to inflammation, genic expression, and regulation of cell survival.
Despite the wealth of data from animal studies, there is a relative lack of data concerning human beings, even if some positive results are beginning to emerge. Therefore, blueberry polyphenols could become useful pharmacological agents for various conditions including neurological diseases, but further studies are still necessary to attain this objective.
本研究旨在强调蓝莓多酚对中枢神经系统（CNS）的作用及其可能的作用机制。
按时间顺序对该主题的重要文献进行了分析，并将结果与主要涉及 CNS 的有益和保护作用相关联。
在过去的 10 年中，科学界对多酚的兴趣日益浓厚，蓝莓中富含多酚，因为它们被认为具有神经保护作用，并可能降低与年龄相关的认知和运动能力下降，这可以通过补充饮食的动物模型的功能改善来证明。这些作用不仅可以通过纯粹的抗氧化作用来解释，还可以通过与炎症、基因表达和细胞存活调节相关的更复杂的机制来解释。
尽管动物研究的数据丰富，但关于人类的相关数据相对较少，尽管已经开始出现一些积极的结果。因此，蓝莓多酚可能成为包括神经疾病在内的各种疾病的有用的药理学制剂，但仍需要进一步的研究来实现这一目标。
