Thamboo Andrew, Mori Tyler, Chau Justin, Pijl Sipke, Westerberg Brian D
University of British Columbia.
Cochlear Implants Int. 2010 Jun;11(2):65-70. doi: 10.1179/146701010X486462.
To determine whether peri-operative minocycline improves preservation of residual hearing in adult patients undergoing cochlear implantation.
Retrospective age, gender matched study design.
Tertiary/quaternary referral centre.
Nine patients undergoing cochlear implantation who received minocycline peri-operatively and a historical control group of nine matched patients who did not receive minocycline.
INTERVENTION(S): Minocycline 200mg orally pre-operatively and 100mg daily post-operatively for ten days.
MAIN OUTCOME MEASURE(S): Change in residual hearing thresholds at 250 and 500 Hz.
The average loss of residual hearing at 250 Hz post-cochlear implant for those who had not received minocycline was 18.9 dB (SD 12.2) compared to 16.7 dB (SD 15.0) for those who had received peri-operative minocycline (p-value 0.77). The average loss of residual hearing at 500 Hz post-cochlear implant for those who had not received minocycline was 24.4 dB (SD 15.9) compared to 19.4 dB (SD 14.3) for those who had received minocycline (p-value 0.48). Two patients who did not receive minocycline lost all residual hearing at both 250 Hz and 500 Hz post-implantation and only one patient who had received minocycline lost all residual hearing at 500 Hz.
The neuroprotective effect of minocycline may help to preserve residual hearing post-cochlear implant. Further studies are warranted.
确定围手术期使用米诺环素是否能改善接受人工耳蜗植入的成年患者残余听力的保留情况。
回顾性年龄、性别匹配研究设计。
三级/四级转诊中心。
9例接受人工耳蜗植入且围手术期使用米诺环素的患者，以及9例匹配的未使用米诺环素的历史对照组患者。
术前口服米诺环素200mg，术后每日口服100mg，共10天。
250Hz和500Hz时残余听力阈值的变化。
未接受米诺环素治疗的患者人工耳蜗植入后250Hz时残余听力的平均损失为18.9dB（标准差12.2），而接受围手术期米诺环素治疗的患者为16.7dB（标准差15.0）（p值0.77）。未接受米诺环素治疗的患者人工耳蜗植入后500Hz时残余听力的平均损失为24.4dB（标准差15.9），而接受米诺环素治疗的患者为19.4dB（标准差14.3）（p值0.48）。2例未接受米诺环素治疗的患者植入后在250Hz和500Hz时均丧失了所有残余听力，而仅1例接受米诺环素治疗的患者在500Hz时丧失了所有残余听力。
米诺环素的神经保护作用可能有助于保留人工耳蜗植入后的残余听力。有必要进行进一步研究。
