PPARG 基因启动子多态性与老年斯洛文尼亚人群非外伤性髋部骨折风险相关：一项初步研究。

PPARG gene promoter polymorphism is associated with non-traumatic hip fracture risk in the elderly Slovenian population: a pilot study.

机构信息

University of Ljubljana, Faculty of Pharmacy, Department of Clinical Biochemistry, Aškerčeva cesta 7, SI 1000, Ljubljana, Slovenia.

General and Teaching Hospital Celje, Department of Traumatology, Oblakova ulica 5, SI 3000, Celje, Slovenia.

出版信息

Clin Biochem. 2011 Sep;44(13):1085-1089. doi: 10.1016/j.clinbiochem.2011.06.981. Epub 2011 Jul 6.

DOI:10.1016/j.clinbiochem.2011.06.981

PMID:21756892

Abstract

OBJECTIVES

Peroxisome proliferator-activated receptor γ (PPARγ), an essential transcription factor for adipogenesis, has been implicated in pathogenesis of osteoporosis. The association of three single nucleotide polymorphisms in the PPARG gene with hip fracture risk, bone mineral density (BMD) and biochemical markers of bone turnover was investigated in the elderly.

DESIGN AND METHODS

Six hundred sixty-seven elderly Slovenians were genotyped for SNPs rs12497191, rs1801282 and rs3856806. BMD and biochemical markers of bone turnover were measured. Haplotypes ACC, AGT and GCC, defined by rs12497191, rs1801282 and rs3856806 were assigned. Influence of genotype on fracture risk was assessed in 72 non-traumatic hip fracture cases and 272 controls.

RESULTS

The rs12497191 G allele alone or in haplotype was associated with lower risk of non-traumatic hip fracture and higher serum receptor activator of nuclear factor κB ligand.

CONCLUSIONS

The rs12497191 genotype could contribute to the incidence of non-traumatic hip fractures in the elderly.

摘要

目的

过氧化物酶体增殖物激活受体 γ（PPARγ）是脂肪生成的必需转录因子，与骨质疏松症的发病机制有关。本研究旨在探讨 PPARG 基因中的三个单核苷酸多态性与髋部骨折风险、骨密度（BMD）和骨转换生化标志物之间的关系。

设计和方法

对 667 名斯洛文尼亚老年人进行了 rs12497191、rs1801282 和 rs3856806 单核苷酸多态性的基因分型。测量了 BMD 和骨转换的生化标志物。根据 rs12497191、rs1801282 和 rs3856806 定义了 SNP rs12497191、rs1801282 和 rs3856806 的单倍型 ACC、AGT 和 GCC。通过 72 例非创伤性髋部骨折病例和 272 例对照评估了基因型对骨折风险的影响。