Department of Clinical and Health Psychology, University of Florida, Gainesville, FL 32610, United States.
Int J Psychophysiol. 2011 Oct;82(1):97-106. doi: 10.1016/j.ijpsycho.2011.06.019. Epub 2011 Jul 12.
Continuous monitoring of one's performance is invaluable for guiding behavior towards successful goal attainment by identifying deficits and strategically adjusting responses when performance is inadequate. In the present study, we exploited the advantages of event-related functional magnetic resonance imaging (fMRI) to examine brain activity associated with error-related processing after severe traumatic brain injury (sTBI). fMRI and behavioral data were acquired while 10 sTBI participants and 12 neurologically-healthy controls performed a task-switching cued-Stroop task. fMRI data were analyzed using a random-effects whole-brain voxel-wise general linear model and planned linear contrasts. Behaviorally, sTBI patients showed greater error-rate interference than neurologically-normal controls. fMRI data revealed that, compared to controls, sTBI patients showed greater magnitude error-related activation in the anterior cingulate cortex (ACC) and an increase in the overall spatial extent of error-related activation across cortical and subcortical regions. Implications for future research and potential limitations in conducting fMRI research in neurologically-impaired populations are discussed, as well as some potential benefits of employing multimodal imaging (e.g., fMRI and event-related potentials) of cognitive control processes in TBI.
持续监测个人表现对于指导行为以实现成功的目标至关重要，通过识别缺陷并在表现不足时进行策略性调整，可以实现这一目标。在本研究中，我们利用事件相关功能磁共振成像（fMRI）的优势，研究了严重创伤性脑损伤（sTBI）后与错误相关处理相关的大脑活动。在 10 名 sTBI 参与者和 12 名神经正常的对照组进行提示转换 Stroop 任务时，获取了 fMRI 和行为数据。使用随机效应全脑体素-wise 广义线性模型和计划线性对比分析 fMRI 数据。行为上，sTBI 患者的错误率干扰比神经正常对照组更大。fMRI 数据显示，与对照组相比，sTBI 患者在前扣带皮层（ACC）中显示出更大的错误相关激活幅度，并且错误相关激活在皮质和皮质下区域的整体空间范围增加。讨论了未来研究的意义以及在神经损伤人群中进行 fMRI 研究的潜在限制，以及在 TBI 中采用认知控制过程的多模态成像（例如 fMRI 和事件相关电位）的一些潜在益处。
