伊曲康唑口服治疗空洞型肺癌合并曲菌球

Oral treatment with itraconazole of aspergilloma in cavitary lung cancer.

作者信息

Impens N, De Greve J, De Beule K, Meysman M, De Beuckelaere S, Schandevyl W

机构信息

Dept of pneumology, A.Z. VUB, Vrije Universiteit, Brussel, Belgium.

出版信息

Eur Respir J. 1990 Jul;3(7):837-9.

PMID:2175709

Abstract

We report a case of aspergilloma in a necrotic small cell lung cancer, where poor pulmonary function and performance status of the patient precluded surgical treatment. High dose Itraconazole, a new oral anti-mycotic drug, was given for 13 months. During this treatment there was a decrease of the fungus ball size and no haemoptysis. Moreover control of the aspergilloma allowed chemotherapeutic treatment of the underlying bronchocarcinoma.

摘要

我们报告一例坏死性小细胞肺癌合并曲菌球的病例，该患者肺功能差且身体状况不佳，无法进行手术治疗。给予高剂量的新型口服抗真菌药物伊曲康唑治疗13个月。在此治疗期间，真菌球大小减小，且未发生咯血。此外，曲菌球得到控制后，得以对 underlying 支气管癌进行化疗。（注：原文中“underlying”疑有误，结合语境可能是“基础的”意思，这里按此理解翻译，若有更准确信息可进一步完善。）