Orgad S, Brewis N D, Alphey L, Axton J M, Dudai Y, Cohen P T
Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
FEBS Lett. 1990 Nov 26;275(1-2):44-8. doi: 10.1016/0014-5793(90)81435-q.
cDNA coding for protein phosphatase 2A (PP2A) has been isolated from Drosophila head and eye imaginal disc libraries. Drosophila PP2A mRNA is expressed throughout development, but is most abundant in the early embryo. The cDNA hybridises to a single site on the left arm of the second chromosome at position 28D2-4. The deduced amino acid sequence (309 residues) of Drosophila PP2A shows 94% identity with either rabbit PP2A alpha or PP2A beta, indicating that PP2A may be the most conserved of all known enzymes.
编码蛋白磷酸酶2A（PP2A）的互补DNA（cDNA）已从果蝇头部和眼成虫盘文库中分离出来。果蝇PP2A信使核糖核酸（mRNA）在整个发育过程中均有表达，但在早期胚胎中最为丰富。该cDNA与第二条染色体左臂上28D2 - 4位置的单个位点杂交。果蝇PP2A推导的氨基酸序列（309个残基）与兔PP2Aα或PP2Aβ的序列一致性达94%，这表明PP2A可能是所有已知酶中最保守的。
