Vongsavan N, Pavasuthipaisit K, Rakprasitkul S, Kitiyanant Y
Department of Physiology & Biochemistry, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.
J Med Assoc Thai. 1990 Aug;73(8):443-9.
An experiment was conducted to evaluate the responses of plasma stress hormones (beta-endorphin, ACTH and cortisol) to third molar surgery, and the effect of diazepam pretreatment on these responses. Eleven patients who required surgical removal of two lower impacted molars (left and right) were studied. The results showed that plasma beta-endorphin, ACTH and cortisol levels were increased significantly during surgery and decreased to baseline levels 30 minutes after completion of the operation in nonsedated patients. When diazepam was premedicated intravenously, elevations of ACTH and cortisol were abolished. Plasma beta-endorphin was still increased but significantly blocked by diazepam pretreatment.
进行了一项实验，以评估血浆应激激素（β-内啡肽、促肾上腺皮质激素和皮质醇）对第三磨牙手术的反应，以及地西泮预处理对这些反应的影响。研究了11名需要手术拔除两颗下颌阻生磨牙（左右各一颗）的患者。结果显示，在未使用镇静剂的患者中，手术期间血浆β-内啡肽、促肾上腺皮质激素和皮质醇水平显著升高，术后30分钟降至基线水平。静脉注射地西泮进行术前用药时，促肾上腺皮质激素和皮质醇的升高被消除。血浆β-内啡肽仍会升高，但地西泮预处理可显著抑制其升高。
