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本文引用的文献

1
Processing of X-ray diffraction data collected in oscillation mode.振荡模式下收集的X射线衍射数据的处理。
Methods Enzymol. 1997;276:307-26. doi: 10.1016/S0076-6879(97)76066-X.
2
Fatty acid binding proteins: potential chaperones of cytosolic drug transport in the enterocyte?脂肪酸结合蛋白：肠细胞胞质药物转运的潜在伴侣蛋白？
Pharm Res. 2011 Sep;28(9):2176-90. doi: 10.1007/s11095-011-0446-1. Epub 2011 Apr 27.
3
A nuclear magnetic resonance-based structural rationale for contrasting stoichiometry and ligand binding site(s) in fatty acid-binding proteins.基于核磁共振的结构原理，解释了脂肪酸结合蛋白在配体结合部位的化学计量数和结合位点为何存在差异。
Biochemistry. 2011 Mar 1;50(8):1283-95. doi: 10.1021/bi101307h. Epub 2011 Feb 2.
4
Natural ligand binding and transfer from liver fatty acid binding protein (LFABP) to membranes.天然配体与肝脏脂肪酸结合蛋白（LFABP）结合并向膜转移。
Biochim Biophys Acta. 2010 Sep;1801(9):1082-9. doi: 10.1016/j.bbalip.2010.05.008. Epub 2010 Jun 10.
5
Liver fatty acid-binding protein and obesity.肝脂肪酸结合蛋白与肥胖。
J Nutr Biochem. 2010 Nov;21(11):1015-32. doi: 10.1016/j.jnutbio.2010.01.005.
6
PHENIX: a comprehensive Python-based system for macromolecular structure solution.PHENIX：一个基于Python的用于大分子结构解析的综合系统。
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):213-21. doi: 10.1107/S0907444909052925. Epub 2010 Jan 22.
7
Hepatic phenotype of liver fatty acid binding protein gene-ablated mice.肝脏脂肪酸结合蛋白基因敲除小鼠的肝脏表型
Am J Physiol Gastrointest Liver Physiol. 2009 Dec;297(6):G1053-65. doi: 10.1152/ajpgi.00116.2009. Epub 2009 Oct 8.
8
Structural and functional analysis of fatty acid-binding proteins.脂肪酸结合蛋白的结构与功能分析
J Lipid Res. 2009 Apr;50 Suppl(Suppl):S126-31. doi: 10.1194/jlr.R800084-JLR200. Epub 2008 Nov 17.
9
Amelioration of diabetic tubulointerstitial damage in liver-type fatty acid-binding protein transgenic mice.肝型脂肪酸结合蛋白转基因小鼠糖尿病性肾小管间质损伤的改善
Nephrol Dial Transplant. 2009 Mar;24(3):788-800. doi: 10.1093/ndt/gfn573. Epub 2008 Oct 14.
10
Crystal structure of soluble domain of malaria sporozoite protein UIS3 in complex with lipid.疟原虫子孢子蛋白UIS3可溶性结构域与脂质复合物的晶体结构
J Biol Chem. 2008 Aug 29;283(35):24077-88. doi: 10.1074/jbc.M801946200. Epub 2008 Jun 23.

脂肪酸诱导的人肝脂肪酸结合蛋白结构重排。

Fatty acid induced remodeling within the human liver fatty acid-binding protein.

机构信息

Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Road, 110067 New Delhi, India.

出版信息

J Biol Chem. 2011 Sep 9;286(36):31924-8. doi: 10.1074/jbc.M111.270165. Epub 2011 Jul 8.

DOI:10.1074/jbc.M111.270165
PMID:21757748
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3173104/
Abstract

We crystallized human liver fatty acid-binding protein (LFABP) in apo, holo, and intermediate states of palmitic acid engagement. Structural snapshots of fatty acid recognition, entry, and docking within LFABP support a heads-in mechanism for ligand entry. Apo-LFABP undergoes structural remodeling, where the first palmitate ingress creates the atomic environment for placement of the second palmitate. These new mechanistic insights will facilitate development of pharmacological agents against LFABP.

摘要

我们将人肝脂肪酸结合蛋白（LFABP）在 apo、holo 和棕榈酸结合的中间状态下进行结晶。脂肪酸识别、进入和与 LFABP 对接的结构快照支持配体进入的头部向内机制。apo-LFABP 经历结构重塑，其中第一个棕榈酸进入创造了第二个棕榈酸放置的原子环境。这些新的机制见解将有助于开发针对 LFABP 的药物。