与年龄相关性黄斑变性相关的遗传因素。
Genetic factors associated with age-related macular degeneration.
机构信息
Department of Ophthalmology, Hôpital Intercommunal de Créteil, University of Paris XII, Créteil, France.
出版信息
Ophthalmologica. 2011;226(3):87-102. doi: 10.1159/000328981. Epub 2011 Jul 14.
PMID:21757876
Abstract
Age-related macular degeneration (AMD) is a complex, multifactorial disease associated with environmental and genetic factors. This review emphasizes the clinical impact of the major genetic factors mainly located in the complement factor H gene and on the 10q26 locus, and their current and future implications for the management of AMD.
摘要
年龄相关性黄斑变性（AMD）是一种复杂的多因素疾病，与环境和遗传因素有关。本综述强调了主要遗传因素的临床影响，这些遗传因素主要位于补体因子 H 基因和 10q26 基因座上，以及它们对 AMD 管理的当前和未来意义。
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