Weaver M G, Abdul-Karim F W, Dale G, Sorensen K, Huang Y T
Institute of Pathology, Case Western Reserve University, University Hospitals of Cleveland, Ohio.
Mod Pathol. 1990 Nov;3(6):679-83.
In situ hybridization with biotinylated DNA viral probes (ISH-B) for human papillomavirus (HPV) types 6/11, 16, 18, 31, and 33 was used to study the outcome in 32 cases of mild and 21 cases of moderate cervical dysplasia with koilocytotic change that were followed for an average of 27 mo. The rates of regression, persistence, and progression for cervical intraepithelial neoplasia (CIN) I and CIN II were 50%, 41%, and 9%, and 43%, 48%, and 9%, respectively. While progression of HPV 16 CIN I and II lesions was observed, regression occurred in 80% (four of five) and 43% (three of seven) of CIN I and II HPV 16-positive lesions, respectively. Regression was also seen in lesions that contained HPV 31 or HPV 33. All of the HPV 18 lesions persisted. The findings are compared with those of previous studies. Since some of the assumed more aggressive viral types can regress when followed by cytologic and biopsy examinations, caution must be exercised when attempting to predict the clinical outcome based solely on the specific viral type present in a given CIN lesion.
采用生物素化DNA病毒探针原位杂交法（ISH-B）检测人乳头瘤病毒（HPV）6/11、16、18、31和33型，对32例轻度和21例中度伴有挖空细胞改变的宫颈发育异常患者进行研究，平均随访27个月。宫颈上皮内瘤变（CIN）I级和II级的消退、持续和进展率分别为50%、41%和9%，以及43%、48%和9%。虽然观察到HPV 16型CIN I级和II级病变有进展，但CIN I级和II级HPV 16阳性病变分别有80%（5例中的4例）和43%（7例中的3例）发生消退。在含有HPV 31或HPV 33的病变中也观察到消退。所有HPV 18型病变均持续存在。将这些结果与先前的研究结果进行了比较。由于某些被认为更具侵袭性的病毒类型在细胞学和活检检查随访时可发生消退，因此在仅根据特定CIN病变中存在的病毒类型来预测临床结果时必须谨慎。
