Johnson K F, Chan W, Kornfeld S
Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Proc Natl Acad Sci U S A. 1990 Dec;87(24):10010-4. doi: 10.1073/pnas.87.24.10010.
The signals required for rapid internalization of the bovine cation-dependent mannose 6-phosphate receptor have been localized to two distinct regions of the 67-amino acid cytoplasmic domain. One signal includes phenylalanine 13 and phenylalanine 18, while the other involves tyrosine 45. The former signal is more potent than the latter, but both must be present for the maximal rate of receptor internalization. Each signal shares similarities with the known internalization signals of other recycling receptors.
牛阳离子依赖性甘露糖6-磷酸受体快速内化所需的信号已定位到67个氨基酸的细胞质结构域的两个不同区域。一个信号包括苯丙氨酸13和苯丙氨酸18，而另一个涉及酪氨酸45。前一个信号比后一个信号更强，但两者都必须存在才能实现受体内化的最大速率。每个信号都与其他循环受体的已知内化信号有相似之处。
