Ullbro C, Alm T, Ericson S, Koch G, Schiöler R
Department of Pedodontics, Public Dental Service, Skövde, Sweden.
Swed Dent J. 1990;14(5):201-12.
Osteomatous jaw lesions have been reported to occur in connection with familial adenomatous polyposis (FAP) of the intestines. The disease is fatal if not treated. The aim of this investigation was to study the occurrence of bone jaw lesions in Swedish families, where some family members have developed FAP, in order to evaluate if these bone changes may be regarded as clinical markers of the disease. 132 individuals from ten families with FAP and a matched control group of 250 individuals were examined. Osteomatous lesions were diagnosed in 24 per cent in the FAP families and in 2 per cent in the controls. Individuals with verified FAP showed an increased occurrens of jaw lesions. Also in family members without verified FAP, first-degree relatives and other relatives, showed a significant higher incidence of osteomatous jaw lesions compared to the controls. Our results suggest that osteomatous jaw lesions in families with FAP are of predictive significance.
据报道，骨化性颌骨病变与家族性腺瘤性息肉病（FAP）相关。如果不进行治疗，该疾病将是致命的。本研究的目的是研究瑞典一些家庭成员患FAP的家庭中骨化性颌骨病变的发生情况，以评估这些骨骼变化是否可被视为该疾病的临床标志物。对来自10个患有FAP的家庭的132名个体和一个由250名个体组成的匹配对照组进行了检查。在FAP家庭中，24%的个体被诊断出有骨化性病变，而在对照组中这一比例为2%。确诊为FAP的个体颌骨病变发生率增加。同样，在未确诊为FAP的家庭成员、一级亲属和其他亲属中，与对照组相比，骨化性颌骨病变的发生率也显著更高。我们的结果表明，FAP家庭中的骨化性颌骨病变具有预测意义。
