微小RNA在肿瘤发生和血管生成中的作用。
The roles of microRNAs in tumorigenesis and angiogenesis.
作者信息
Yang Weining, Lee Daniel Y, Ben-David Yaacov
出版信息
Int J Physiol Pathophysiol Pharmacol. 2011;3(2):140-55. Epub 2010 Jun 18.
Abstract
MicroRNAs (miRNAs) are short, non-coding sequences that control gene expression via translational regulation. Through interactions with the 3'-untranslated region of messenger RNA, miRNAs trigger translational repression and play a key role in developmental timing. Furthermore, many miRNA groups have now been shown to regulate various processes in tumorigenesis, including angiogenesis and metastasis. These links highlight the importance of microRNA research in further understanding cancer development. This review article summarizes the current state of microRNA research, with a focus on the roles of microRNAs in various cancer types. Up to date knowledge of the structure and biogenesis pathway of microRNA are also reviewed.
摘要
微小RNA（miRNA）是短的非编码序列，通过翻译调控来控制基因表达。通过与信使核糖核酸的3'非翻译区相互作用，miRNA引发翻译抑制，并在发育时间调控中发挥关键作用。此外，现在已经表明许多miRNA组可调节肿瘤发生的各种过程，包括血管生成和转移。这些联系凸显了微小RNA研究在进一步理解癌症发展方面的重要性。这篇综述文章总结了微小RNA研究的现状，重点关注微小RNA在各种癌症类型中的作用。同时也回顾了微小RNA的结构和生物合成途径的最新知识。
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