Gross-Isseroff R, Dillon K A, Israeli M, Biegon A
Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
Brain Res. 1990 Oct 22;530(2):312-6. doi: 10.1016/0006-8993(90)91301-v.
The effect of ageing and suicide on mu opioid receptors was studied in the human brain postmortem. Quantitative autoradiography with [3H]DAGO revealed region specific increases in mu receptor density with age. Suicide was accompanied by a significant increase, up to 9-fold, in mu receptor density in the young, but not the old, subjects as compared to age-matched controls. This effect was evident in the frontal and temporal cortical gyri. Saturation binding studies with the same ligand show that the increased binding in the elderly and in the young suicides is due to an increase in receptor density (Bmax) rather than affinity (Kd).
在人脑尸检中研究了衰老和自杀对μ阿片受体的影响。用[3H]DAGO进行的定量放射自显影显示，μ受体密度随年龄增长呈现区域特异性增加。与年龄匹配的对照组相比，自杀导致年轻受试者（而非老年受试者）的μ受体密度显著增加，增幅高达9倍。这种效应在额叶和颞叶皮质回中很明显。用相同配体进行的饱和结合研究表明，老年人和年轻自杀者中结合增加是由于受体密度（Bmax）增加，而非亲和力（Kd）增加。
