Department of Psychiatry, Yamagata University School of Medicine, Yamagata, Japan.
Department of Anatomy and Cell Biology, Yamagata University School of Medicine, Yamagata, Japan.
Brain Behav. 2022 Jul;12(7):e2674. doi: 10.1002/brb3.2674. Epub 2022 Jun 27.
The μ-opioid receptor (MOR) plays an important role in social bonding behaviors, while it is implicated in the pathophysiology of depression. It is shown that the A118G polymorphism (rs1799971) of the MOR gene (OPRM1) causes amino-acid exchange from Asn to Asp, and that this polymorphism is associated with altered mu-opioid receptor function. Meanwhile, sociotropy/autonomy and interpersonal sensitivity are personality vulnerabilities to depression characterized by distinctive interpersonal styles. The present study tested the hypothesis that the functional A118G OPRM1 polymorphism influences these personality traits.
The subjects were 402 physically and mentally healthy Japanese volunteers. Sociotropy and autonomy were measured by the Sociotropy-Autonomy Scale, and interpersonal sensitivity was evaluated by the Interpersonal Sensitivity Measure. The A118G polymorphism of the OPRM1 was determined by the PCR method.
In one factor analysis of covariance, there were differences in scores of sociotropy (uncorrected p < .001, corrected p < .003) and interpersonal sensitivity (uncorrected p = .015, corrected p = .045), but not autonomy, among the A/A, A/G, and G/G genotypes. Post hoc LSD tests showed that sociotropy scores were higher in the A/A group than in the A/G (p = .029) and G/G (p < .001) groups, and higher in the A/G group than in the G/G group (p = .004). Interpersonal sensitivity scores were higher in the A/A group than in the A/G (p = .023) and G/G (p = .009) groups.
This study suggests that the A118G OPRM1 polymorphism is associated with sociotropy and interpersonal sensitivity, interpersonal vulnerabilities to depression.
μ-阿片受体（MOR）在社交结合行为中发挥重要作用，而它与抑郁症的病理生理学有关。研究表明，MOR 基因（OPRM1）的 A118G 多态性（rs1799971）导致氨基酸从天冬酰胺到天冬氨酸的交换，这种多态性与改变的μ-阿片受体功能有关。同时，社交倾向/自主性和人际敏感性是抑郁的人格脆弱性，表现为独特的人际风格。本研究检验了功能 A118G OPRM1 多态性是否影响这些人格特质的假设。
研究对象为 402 名身心健康的日本志愿者。社交倾向和自主性通过社交倾向-自主性量表测量，人际敏感性通过人际敏感性量表评估。OPRM1 的 A118G 多态性通过 PCR 法确定。
在协方差的单因素分析中，在社交倾向（未校正 p<.001，校正 p<.003）和人际敏感性（未校正 p=0.015，校正 p=0.045）方面存在差异，但在自主性方面没有差异，在 A/A、A/G 和 G/G 基因型之间。事后 LSD 检验显示，A/A 组的社交倾向评分高于 A/G（p=0.029）和 G/G（p<.001）组，A/G 组高于 G/G 组（p=0.004）。A/A 组的人际敏感性评分高于 A/G（p=0.023）和 G/G（p=0.009）组。
本研究表明，OPRM1 的 A118G 多态性与社交倾向和人际敏感性有关，是抑郁的人际易感性。
