Matsushima K, Shinohara Y, Yamamoto M
Department of Neurology, Tokai University School of Medicine.
Rinsho Shinkeigaku. 1990 Sep;30(9):1013-6.
A case of facial diplegia due to EB virus infection is reported. A 56-year-old man developed headache, arthralgia and low grade fever. Two days later he noted dysesthesia of the bilateral extremities. Eight days later, disturbances of bilateral mouth and eye closing appeared, which brought him to our hospital on January 6, 1986. Neurological examinations disclosed bilateral peripheral facial palsy and glove and stocking type sensory impairment. Muscle weakness, pathological reflexes were not noted. Examination of CSF on admission revealed a cell count of 63/mm3 and a protein concentration of 45 mg/dl. The lumbar puncture, done 7 days later, revealed a cell count of 17/mm3, and a protein concentration of 41 mg/dl. Serum Epstein-Barr virus titers were times 40 (VCA IgG) and less than X10 (EBNA) on admission. Nine days later, serum EB virus titer increased to times 160 (VCA IgG). He was diagnosed as having polyneuropathy due to EB virus infection from the clinical manifestations and serum antibody titer for EB virus. EB virus infection produces various neurological manifestations. Facial nerve palsy is reported as one of the rare complications. However, most of these cases are associated with Guillain-Barré syndrome (GBS). As far as we know, only 10 cases of bilateral facial nerve palsy in the absence of GBS have appeared in the literature. In our case, bilateral facial nerve palsy appeared as a part of polyneuropathy in the absence of GBS. EB virus should be considered as one of etiologies of bilateral facial nerve palsy.
报告了1例因EB病毒感染导致的双侧面瘫病例。一名56岁男性出现头痛、关节痛和低热。两天后,他注意到双侧肢体感觉异常。八天后,出现双侧闭眼和闭嘴障碍,于1986年1月6日前来我院就诊。神经系统检查发现双侧周围性面瘫以及手套和袜套样感觉障碍。未发现肌肉无力和病理反射。入院时脑脊液检查显示细胞计数为63/mm³,蛋白浓度为45mg/dl。7天后进行的腰椎穿刺显示细胞计数为17/mm³,蛋白浓度为41mg/dl。入院时血清EB病毒滴度为40倍(VCA IgG)且小于10倍(EBNA)。九天后,血清EB病毒滴度升至160倍(VCA IgG)。根据临床表现和EB病毒血清抗体滴度,他被诊断为EB病毒感染所致的多发性神经病。EB病毒感染可产生多种神经表现。面神经麻痹被报道为罕见并发症之一。然而,这些病例大多与吉兰 - 巴雷综合征(GBS)相关。据我们所知,文献中仅出现过10例无GBS的双侧面神经麻痹病例。在我们的病例中,双侧面神经麻痹是在无GBS的情况下作为多发性神经病的一部分出现的。EB病毒应被视为双侧面神经麻痹的病因之一。