Department of Neurobiology and Anatomy, 401 MREB, University of Utah, Salt Lake City, Utah 84132, USA.
Dev Dyn. 2011 Aug;240(8):2034-41. doi: 10.1002/dvdy.22688.
In 2006, Yamanaka's group announced they had discovered the proverbial "fountain of youth" for human cells, forever changing the field of stem cell research. After misexpressing within them a cocktail of four genes, adult somatic cells revert into an embryonic stem cell (ESC)-like state. These so-called induced pluripotent stem cells (iPSCs) can differentiate into a wide variety of cell types, seemingly bypassing the need for politically charged ESCs. However, iPSCs differ from ESCs in potentially deleterious ways, precluding their use in regenerative medicine. In this primer and adjoining discussion with iPSC biologists William Lowry, PhD, and Clive Svendsen, PhD, we explore these issues as well how iPSCs promise to contribute to the understanding of developmental biology and the etiology, and treatment, of human diseases.
2006 年，山中伸弥的团队宣布他们发现了人类细胞的“不老泉”，这一发现永远改变了干细胞研究领域。他们在其中错误表达了四种基因的混合物，使成体细胞恢复到胚胎干细胞（ESC）样状态。这些所谓的诱导多能干细胞（iPSC）可以分化为多种细胞类型，似乎绕过了需要使用具有政治争议的 ESC。然而，iPSC 在潜在的有害方面与 ESC 不同，这排除了它们在再生医学中的应用。在这个入门读物中，我们与 iPSC 生物学家 William Lowry，PhD 和 Clive Svendsen，PhD 一起探讨了这些问题，以及 iPSC 如何有望促进对发育生物学以及人类疾病的病因和治疗的理解。
