Research Institute, Diagnostic Imaging, Hospital for Sick Children, Toronto, Canada.
J Magn Reson Imaging. 2011 Sep;34(3):608-15. doi: 10.1002/jmri.22660. Epub 2011 Jul 14.
To provide the first comparison of absolute renal perfusion obtained by arterial spin labeling (ASL) and separable compartment modeling of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI). Moreover, we provide the first application of the dual bolus approach to quantitative DCE-MRI perfusion measurements in the kidney.
Consecutive ASL and DCE-MRI acquisitions were performed on six rabbits on a 1.5 T MRI system. Gadolinium (Gd)-DTPA was administered in two separate injections to decouple measurement of the arterial input function and tissue uptake curves. For DCE perfusion, pixel-wise and mean cortex region-of-interest tissue curves were fit to a separable compartment model.
Absolute renal cortex perfusion estimates obtained by DCE and ASL were in close agreement: 3.28 ± 0.59 mL/g/min (ASL), 2.98 ± 0.60 mL/g/min (DCE), and 3.57 ± 0.96 mL/g/min (pixel-wise DCE). Renal medulla perfusion was 1.53 ± 0.35 mL/g/min (ASL) but was not adequately described by the separable compartment model.
ASL and DCE-MRI provided similar measures of absolute perfusion in the renal cortex, offering both noncontrast and contrast-based alternatives to improve current renal MRI assessment of kidney function.
首次比较动脉自旋标记（ASL）和动态对比增强（DCE）磁共振成像（MRI）的可分离隔室模型获得的绝对肾灌注。此外，我们首次将双脉冲法应用于肾脏定量 DCE-MRI 灌注测量。
在 1.5 T MRI 系统上对 6 只兔子进行连续的 ASL 和 DCE-MRI 采集。两次单独注射钆（Gd）-DTPA 以解耦动脉输入函数和组织摄取曲线的测量。对于 DCE 灌注，像素和平均皮质 ROI 组织曲线拟合可分离隔室模型。
DCE 和 ASL 获得的绝对肾皮质灌注估计值非常吻合：3.28 ± 0.59 mL/g/min（ASL）、2.98 ± 0.60 mL/g/min（DCE）和 3.57 ± 0.96 mL/g/min（像素 DCE）。肾髓质灌注为 1.53 ± 0.35 mL/g/min（ASL），但可分离隔室模型不能很好地描述。
ASL 和 DCE-MRI 均可提供肾皮质绝对灌注的相似测量值，为改善当前的肾脏 MRI 肾功能评估提供了非对比和对比增强的替代方法。
