少感多肝对四氯化碳诱导的亚急性肝损伤大鼠肝细胞线粒体的保护作用
[Protective effects of shaoganduogan on hepatocyte mitochondria in subacute liver injury rat induced by carbon tetrachloride].
作者信息
Song Jun, Zhao Junning, Wang Xiaodong, Dai Ying, Deng Zhiwen, Yi Jinhai
机构信息
Institute of Pharmacology and Toxicology, Sichuan Academy of Chinese Medicine Science, Key Laboratory of Biological Evaluation of Traditional Chinese Medicine Quality of the State Administration of Traditional Chinese Medicine, Key Laboratory of Evaluation of Chinese Herbal Quality of Sichuan Province, Chendu 610041, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2011 Apr;36(7):931-4.
OBJECTIVE
To study the protective effect of Shaoganduogan (SGDG) on serum transaminase, liver pathology and hepatocyte mitochondria in rat with subacute liver injury induced by carbon tetrachloride.
METHOD
Subacute liver injury of rats were induced by carbon tetrachloride, and cured by different doses of SGDG through intragastric administration. The activity of serum ALT, AST, liver pathology and ultrastructure, activity of ATPase, SOD and content of MDA of hepatocyte mitochondria were observed.
RESULT
SGDG can remarkably reduce the transaminase, alleviate the degeneration and necrosis of liver cells ,enhance activity of Na+ -K+ ATPase, Ca2+ ATPase, SOD, reduce content of MDA of mitochondria, alleviate ultrastructure change of mitochondria, reduce section area, perimeter equivalent diameter and average optical density perimeter of liver cells.
CONCLUSION
SGDG has obvious effect of liver protection, the mechanisms are related with alleviating mitochondria injury.
目的
研究少甘多苷（SGDG）对四氯化碳诱导的亚急性肝损伤大鼠血清转氨酶、肝脏病理及肝细胞线粒体的保护作用。
方法
采用四氯化碳诱导大鼠亚急性肝损伤，通过灌胃给予不同剂量的SGDG进行治疗。观察血清谷丙转氨酶（ALT）、谷草转氨酶（AST）活性、肝脏病理及超微结构、肝细胞线粒体ATP酶活性、超氧化物歧化酶（SOD）活性及丙二醛（MDA）含量。
结果
SGDG可显著降低转氨酶，减轻肝细胞变性坏死，增强Na+-K+ATP酶、Ca2+ATP酶、SOD活性，降低线粒体MDA含量，减轻线粒体超微结构改变，减小肝细胞截面积、周长等效直径及平均光密度周长。
结论
SGDG具有明显的肝脏保护作用，其机制与减轻线粒体损伤有关。
Zotero 插件