脯氨酸催化醛的α-胺化的动力学分析。

Kinetic profiling of prolinate-catalyzed α-amination of aldehydes.

机构信息

Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA.

出版信息

Org Lett. 2011 Aug 19;13(16):4300-3. doi: 10.1021/ol201639z. Epub 2011 Jul 15.

DOI:10.1021/ol201639z

Abstract

Deconvolution of the role of off-cycle species from the desired catalytic cycle leads to an optimized protocol for the prolinate-catalyzed amination of aldehydes. The scope of complex reaction networks will be greatly broadened by understanding ancillary rate processes that influence the productive catalytic pathway.

摘要

从期望的催化循环中解卷积非循环物种的作用，为脯氨酸催化醛的胺化反应优化了方案。通过了解影响生产性催化途径的辅助速率过程，可以大大拓宽复杂反应网络的范围。