金催化β-酮酯和炔丙胺反应合成 2,5-二氢吡啶衍生物。
Synthesis of 2,5-dihydropyridine derivatives by gold-catalyzed reactions of β-ketoesters and propargylamines.
机构信息
Instituto Universitario de Química Organometálica Enrique Moles, Unidad Asociada al CSIC, Universidad de Oviedo, Julián Clavería 8, 33006-Oviedo, Spain.
出版信息
Org Lett. 2011 Aug 19;13(16):4184-7. doi: 10.1021/ol201655u. Epub 2011 Jul 15.
PMID:21761882
Abstract
The reaction of simple β-ketoesters and propargylamines under gold(III) catalysis leads to the formation of the elusive 2,5-dihydropyridine system. This new reaction provides the synthesis of potentially bioactive compounds in moderate to high yields.
摘要
在金（III）催化下，简单的β-酮酯和炔丙胺反应生成难以捉摸的 2,5-二氢吡啶体系。该新反应为具有潜在生物活性的化合物的合成提供了中等至高产率的方法。
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