Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences and Okayama University Hospital, Okayama, Japan.
Epilepsia. 2011 Oct;52(10):1812-9. doi: 10.1111/j.1528-1167.2011.03169.x. Epub 2011 Jul 18.
We explored high-frequency oscillations (HFOs) in scalp sleep electroencephalography (EEG) studies of patients with idiopathic partial epilepsy (IPE) of childhood in order to obtain a better understanding of the pathologic mechanisms underlying IPE.
The subjects were 45 patients, including 32 with benign childhood epilepsy with centrotemporal spikes (BCECTS) and 13 with Panayiotopoulos syndrome (PS). A total of 136 EEG records were investigated through temporal expansion and filtering of traces and time-frequency spectral analysis.
HFOs with frequency of 93.8-152.3 Hz (mean 126.2 ± 13.6 Hz) in the band of ripples were detected in association with spikes in 97 records (71.3%). Time from last seizure to the EEG recording was significantly shorter in those with spike-related HFOs than in the EEG recordings with spikes without HFOs (p = 0.006). Although time from last seizure reflects age, age at the time of recording was not significantly different between EEG studies with and without HFOs. Peak-power values of the high-frequency spots in time-frequency spectra were significantly negatively correlated with time from last seizure (R(2) = 0.122, p < 0.001) but not with age at the time of recording. Peak frequencies of the high-frequency spectral spots were not significantly correlated with age at the time of recording or with time from last seizure.
The close relationship between the generation of spike-related HFOs and the period of active seizure occurrence indicated that HFOs may tell us more about epileptogenicity in IPE than the spikes themselves. Because there is a spectrum of pediatric epileptic disorders extending from the benign end of BCECTS to the encephalopathic end of epilepsy with continuous spike-waves during slow-wave sleep (CSWS), and HFOs that have already been detected in association with CSWS were more prominent than HFOs in IPE, intense spike-related HFOs may indicate poor prognosis.
我们探索了特发性儿童局灶性癫痫（IPE）患者头皮睡眠脑电图（EEG）中的高频振荡（HFOs），以更好地理解IPE 背后的病理机制。
研究对象为 45 名患者，其中 32 名为良性儿童癫痫伴中央颞区棘波（BCECTS），13 名为 Panayiotopoulos 综合征（PS）。通过迹线的时间扩展和滤波以及时频谱分析对总共 136 份 EEG 记录进行了研究。
在与棘波相关的 97 份记录（71.3%）中检测到频率为 93.8-152.3 Hz（平均值 126.2±13.6 Hz）的涟漪波段 HFOs。与无 HFOs 的棘波 EEG 记录相比，与棘波相关的 HFOs 的 EEG 记录与最近一次癫痫发作之间的时间明显更短（p=0.006）。尽管最近一次癫痫发作的时间反映了年龄，但 EEG 研究中有无 HFOs 的记录之间的年龄记录并无显著差异。时频谱中高频点的峰值功率值与最近一次癫痫发作的时间呈显著负相关（R²=0.122，p<0.001），但与记录时的年龄无关。高频谱点的峰值频率与记录时的年龄或最近一次癫痫发作的时间无显著相关性。
棘波相关 HFOs 的产生与活跃癫痫发作期之间的密切关系表明，与棘波本身相比，HFOs 可能更能反映 IPE 的致痫性。由于从 BCECTS 的良性端到伴有睡眠中棘慢波持续发放的癫痫的脑病端存在一系列儿科癫痫疾病谱，并且已经在 CSWS 中检测到的 HFOs 比 IPE 中的 HFOs 更为突出，因此强烈的棘波相关 HFOs 可能预示着不良预后。
