Halász Péter, Szũcs Anna
Department of Neurology, University Medical School, Pécs, Hungary.
Institute of Behavioral Sciences, Semmelweis University, Budapest, Hungary.
Front Neurol. 2023 Jun 14;14:1092244. doi: 10.3389/fneur.2023.1092244. eCollection 2023.
"." We aimed to review the types of self-limited focal epilepsies..."i.e. keep as two separate paragraphs" We aimed to review the types of self-limited focal epilepsies: (1) self-limited focal childhood epilepsy with centrotemporal spikes, (2) atypical Rolandic epilepsy, and (3) electrical status epilepticus in sleep with mental consequences, including Landau-Kleffner-type acquired aphasia, showing their spectral relationship and discussing the debated topics. Our endeavor is to support the system epilepsy concept in this group of epilepsies, using them as models for epileptogenesis in general. The spectral continuity of the involved conditions is evidenced by several features: language impairment, the overarching presence of centrotemporal spikes and ripples (with changing electromorphology across the spectrum), the essential timely and spatial independence of interictal epileptic discharges from seizures, NREM sleep relatedness, and the existence of the intermediate-severity "atypical" forms. These epilepsies might be the consequences of a genetically determined transitory developmental failure, reflected by widespread neuropsychological symptoms originating from the perisylvian network that have distinct time and space relations from secondary epilepsy itself. The involved epilepsies carry the risk of progression to severe, potentially irreversible encephalopathic forms.
“。”我们旨在回顾自限性局灶性癫痫的类型……“即分成两个单独段落”我们旨在回顾自限性局灶性癫痫的类型：（1）伴有中央颞区棘波的自限性局灶性儿童癫痫，（2）非典型罗兰多癫痫，以及（3）伴有精神后果的睡眠中癫痫性电持续状态，包括Landau - Kleffner型获得性失语，展示它们的频谱关系并讨论有争议的话题。我们的努力是在这组癫痫中支持癫痫系统概念，将它们作为一般癫痫发生的模型。所涉及情况的频谱连续性由几个特征证明：语言障碍、中央颞区棘波和涟漪的普遍存在（频谱上电形态不断变化）、发作间期癫痫放电在时间和空间上与发作基本独立、与非快速眼动睡眠相关以及存在中度严重的“非典型”形式。这些癫痫可能是基因决定的短暂发育失败的后果，表现为源自外侧裂周围网络的广泛神经心理症状，这些症状与继发性癫痫本身有不同的时间和空间关系。所涉及的癫痫有进展为严重的潜在不可逆脑病形式的风险。
