Cserpan Dorottya, Boran Ece, Lo Biundo Santo Pietro, Rosch Richard, Sarnthein Johannes, Ramantani Georgia
Department of Neuropediatrics, University Children's Hospital Zurich, 8032 Zurich, Switzerland.
Department of Neurosurgery, University Hospital Zurich, 8006 Zurich, Switzerland.
Brain Commun. 2021 Mar 23;3(2):fcab052. doi: 10.1093/braincomms/fcab052. eCollection 2021.
High-frequency oscillations in scalp EEG are promising non-invasive biomarkers of epileptogenicity. However, it is unclear how high-frequency oscillations are impacted by age in the paediatric population. We prospectively recorded whole-night scalp EEG in 30 children and adolescents with focal or generalized epilepsy. We used an automated and clinically validated high-frequency oscillation detector to determine ripple rates (80-250 Hz) in bipolar channels. Children < 7 years had higher high-frequency oscillation rates (=0.021) when compared with older children. The median test-retest reliability of high-frequency oscillation rates reached 100% (iqr 50) for a data interval duration of 10 min. Scalp high-frequency oscillation frequency decreased with age ( = -0.558, =0.002), whereas scalp high-frequency oscillation duration and amplitude were unaffected. The signal-to-noise ratio improved with age ( = 0.37, =0.048), and the background ripple band activity decreased with age ( = -0.463, =0.011). We characterize the relationship of scalp high-frequency oscillation features and age in paediatric patients. EEG intervals of 10 min duration are required for reliable measurements of high-frequency oscillation rates. This study is a further step towards establishing scalp high-frequency oscillations as a valid epileptogenicity biomarker in this vulnerable age group.
头皮脑电图中的高频振荡是很有前景的癫痫致痫性无创生物标志物。然而，尚不清楚高频振荡在儿科人群中如何受年龄影响。我们前瞻性地记录了30名患有局灶性或全身性癫痫的儿童和青少年的整夜头皮脑电图。我们使用了一种经过自动检测且经临床验证的高频振荡检测器来确定双极通道中的涟漪率（80 - 250Hz）。与年龄较大的儿童相比，7岁以下儿童的高频振荡率更高（=0.021）。对于10分钟的数据间隔时长，高频振荡率的重测信度中位数达到100%（四分位距50）。头皮高频振荡频率随年龄降低（ = -0.558， =0.002），而头皮高频振荡的持续时间和幅度不受影响。信噪比随年龄改善（ = 0.37， =0.048），背景涟漪带活动随年龄降低（ = -0.463， =0.011）。我们描述了儿科患者头皮高频振荡特征与年龄之间的关系。可靠测量高频振荡率需要10分钟时长的脑电图间期。这项研究朝着将头皮高频振荡确立为这个易受影响年龄组中有效的癫痫致痫性生物标志物又迈进了一步。
