Laboratory of Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatologic Institute (IRCCS) Rome, Italy.
Pigment Cell Melanoma Res. 2011 Aug;24(4):618-30. doi: 10.1111/j.1755-148X.2011.00887.x. Epub 2011 Aug 11.
Given the importance of the tanning response in protecting human skin from the harmful effects of UV radiation, one important research priority is to identify novel molecules that are capable of promoting pigmentation and/or antioxidant defence. Parrodienes share some structural features with carotenoids and retinoids, stimulate cell antioxidant defence and counteract senescence-like phenotype in fibroblasts. We selected the parrodiene-derivative 2,4,6-octatrienoic acid (Octa) to study its impact on key parameters of melanogenesis and antioxidant defence in organ-cultured human skin and in normal human melanocytes. Octa promoted melanogenesis by up-regulating tyrosinase and microphthalmia-associated transcription factor expression. This correlated with an increase of melanin content in both human epidermis in situ and cultured human epidermal melanocytes. Moreover, Octa increased the biological antioxidant potential content and the expression and activity of catalase. Activation of peroxisome proliferator-activated receptor (PPAR)-γ was necessary to evoke these effects. These data strongly encourage the systematic study of Octa as a novel candidate promoter of human skin photoprotection.
鉴于晒黑反应在保护人类皮肤免受紫外线辐射的有害影响方面的重要性，一个重要的研究重点是确定能够促进色素沉着和/或抗氧化防御的新型分子。Parrodienes 与类胡萝卜素和视黄醇具有一些结构特征，刺激细胞抗氧化防御并对抗成纤维细胞中的衰老样表型。我们选择了 Parrodiene 衍生物 2,4,6-辛三烯酸 (Octa) 来研究其对器官培养的人类皮肤和正常人类黑素细胞中黑色素生成和抗氧化防御的关键参数的影响。Octa 通过上调酪氨酸酶和小眼相关转录因子的表达来促进黑色素生成。这与原位人表皮和培养的人表皮黑素细胞中黑色素含量的增加相关。此外，Octa 增加了生物抗氧化潜能含量以及过氧化氢酶的表达和活性。过氧化物酶体增殖物激活受体 (PPAR)-γ 的激活对于引发这些作用是必要的。这些数据强烈鼓励系统地研究 Octa 作为一种新型的人类皮肤光保护促进剂的候选物。
