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皮脂细胞促成黄褐斑的发病。

Sebocytes contribute to melasma onset.

作者信息

Flori Enrica, Mastrofrancesco Arianna, Mosca Sarah, Ottaviani Monica, Briganti Stefania, Cardinali Giorgia, Filoni Angela, Cameli Norma, Zaccarini Marco, Zouboulis Christos C, Picardo Mauro

机构信息

Laboratory of Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatological Institute, IRCCS, Rome, Italy.

Dermatology Department, San Gallicano Dermatological Institute, IRCCS, Rome, Italy.

出版信息

iScience. 2022 Feb 4;25(3):103871. doi: 10.1016/j.isci.2022.103871. eCollection 2022 Mar 18.

DOI:10.1016/j.isci.2022.103871
PMID:35252805
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8891974/
Abstract

Melasma is a hyperpigmentary disorder with photoaging features, whose manifestations appear on specific face areas, rich in sebaceous glands (SGs). To explore the SGs possible contribution to the onset, the expression of pro-melanogenic and inflammatory factors from the SZ95 SG cell line exposed to single or repetitive ultraviolet (UVA) radiation was evaluated. UVA up-modulated the long-lasting production of α-MSH, EDN1, b-FGF, SCF, inflammatory cytokines and mediators. Irradiated SZ95 sebocyte conditioned media increased pigmentation in melanocytes and the expression of senescence markers, pro-inflammatory cytokines, and growth factors regulating melanogenesis in fibroblasts cultures. Cocultures experiments with skin explants confirmed the role of sebocytes on melanogenesis promotion. The analysis on sebum collected from melasma patients demonstrated that sebocytes from lesional areas express the UVA-activated pathways markers observed . Our results indicate sebocytes as one of the actors in melasma pathogenesis, inducing prolonged skin cell stimulation, contributing to localized dermal aging and hyperpigmentation.

摘要

黄褐斑是一种具有光老化特征的色素沉着紊乱疾病，其表现出现在面部富含皮脂腺（SGs）的特定区域。为了探究皮脂腺对黄褐斑发病可能的影响，我们评估了暴露于单次或重复紫外线（UVA）辐射下的SZ95皮脂腺细胞系中促黑素生成因子和炎症因子的表达。UVA上调了α-MSH、内皮素-1（EDN1）、碱性成纤维细胞生长因子（b-FGF）、干细胞因子（SCF）、炎症细胞因子和介质的长期产生。照射后的SZ95皮脂腺细胞条件培养基增加了黑素细胞中的色素沉着以及衰老标志物、促炎细胞因子和调节成纤维细胞培养中黑素生成的生长因子的表达。与皮肤外植体的共培养实验证实了皮脂腺细胞在促进黑素生成中的作用。对黄褐斑患者皮脂的分析表明，来自病变区域的皮脂腺细胞表达了观察到的UVA激活途径标志物。我们的结果表明，皮脂腺细胞是黄褐斑发病机制中的因素之一，可诱导皮肤细胞长期刺激，导致局部皮肤老化和色素沉着。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d981/8891974/4027a5bbb05d/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d981/8891974/b95111294025/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d981/8891974/ad288f3ff3eb/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d981/8891974/2f7d7f8cd38a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d981/8891974/2d4520c56962/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d981/8891974/d31fd255f2b9/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d981/8891974/a77b1ab31499/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d981/8891974/48789477fe56/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d981/8891974/4027a5bbb05d/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d981/8891974/b95111294025/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d981/8891974/ad288f3ff3eb/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d981/8891974/2f7d7f8cd38a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d981/8891974/2d4520c56962/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d981/8891974/d31fd255f2b9/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d981/8891974/a77b1ab31499/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d981/8891974/48789477fe56/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d981/8891974/4027a5bbb05d/gr7.jpg

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