Akiyama M, Takahashi A, Nagatake T, Yamashita H, Yoshida T, Rikitomi N, Ohishi K, Tanaka H, Morito T, Utsunomiya Y
Department of Internal Medicine, Nagasaki University, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1990 Sep;28(9):1174-81.
The efficacy rate, minimal inhibitory concentrations (MICs), and resistance of fluoroquinolone agents against causative organisms in respiratory tract infections from January to March, 1988 were investigated. Of 333 pathogenic strains 85% consisted of 5 major causative organisms of respiratory tract infection (Haemophilus influenzae, Pseudomonas aeruginosa, Streptococcus pneumoniae, Branhamella catarrhalis, and Staphylococcus aureus). In 61 (59 cases) of these 333 strains, including 3 cases of acute pharyngitis, 5 of acute bronchitis, 3 of pneumonia, and 48 of chronic lower respiratory tract infection fluoroquinolone agents were administered. The efficacy rate was 76.3% in all cases, and 75% in cases with chronic lower respiratory tract infection. The fluoroquinolone agents were 100% effective in H. influenzae and B. catarrhalis, though the efficacy rate was 67% in S. aureus and 40% in P. aeruginosa. The susceptibility of all strains to fluoroquinolone agents were investigated. There was no resistant strain in H. influenzae and B. catarrhalis, though resistant strains to fluoroquinolone agents have increased in S. aureus and P. aeruginosa. The efficacy rate was investigated using the MIC of administered fluoroquinolone agent against causative organisms. It is surmised that the efficacy of that agent has an MIC of 1.56-3.13 micrograms/ml.
对1988年1月至3月间呼吸道感染致病微生物的氟喹诺酮类药物的有效率、最低抑菌浓度（MIC）及耐药性进行了研究。在333株病原菌中，85%由呼吸道感染的5种主要致病微生物组成（流感嗜血杆菌、铜绿假单胞菌、肺炎链球菌、卡他布兰汉菌和金黄色葡萄球菌）。在这333株菌株中的61株（59例），包括3例急性咽炎、5例急性支气管炎、3例肺炎和48例慢性下呼吸道感染患者，使用了氟喹诺酮类药物。所有病例的有效率为76.3%，慢性下呼吸道感染病例的有效率为75%。氟喹诺酮类药物对流感嗜血杆菌和卡他布兰汉菌的有效率为100%，而对金黄色葡萄球菌的有效率为67%，对铜绿假单胞菌的有效率为40%。对所有菌株对氟喹诺酮类药物的敏感性进行了研究。流感嗜血杆菌和卡他布兰汉菌中没有耐药菌株，而金黄色葡萄球菌和铜绿假单胞菌中对氟喹诺酮类药物的耐药菌株有所增加。使用所给予的氟喹诺酮类药物对致病微生物的MIC来研究有效率。据推测，该药物的MIC为1.56 - 3.13微克/毫升时具有疗效。
