Department of Neurology, Multiple Sclerosis Center, University of California, San Francisco, CA 94117, USA.
J Neurol Sci. 2011 Dec 15;311(1-2):19-22. doi: 10.1016/j.jns.2011.06.035. Epub 2011 Jul 16.
Vitamin D insufficiency has been shown to be associated with increased susceptibility to multiple sclerosis (MS), but until recently, it was unclear if vitamin D status also influences the prognosis of the disease. In experimental autoimmune encephalomyelitis, a mouse model of MS, the administration of vitamin D reduces the severity of the disease. Initial reports in MS of inverse associations between vitamin D levels and disability or relapse rate were encouraging, but the cross-sectional or retrospective study designs limited their interpretability. More recently, studies of pediatric-onset and adult MS have demonstrated that among those with established MS, those with lower vitamin D levels are at higher risk for subsequent relapse. These observational data provide strong support for randomized controlled trials of vitamin D supplementation in MS.
维生素 D 不足已被证明与多发性硬化症（MS）的易感性增加有关，但直到最近，人们还不清楚维生素 D 状况是否也会影响疾病的预后。在实验性自身免疫性脑脊髓炎（一种 MS 的小鼠模型）中，给予维生素 D 可减轻疾病的严重程度。在 MS 中，最初的报告表明维生素 D 水平与残疾或复发率之间呈负相关，这令人鼓舞，但由于横断面或回顾性研究设计的限制，其解释力有限。最近，对儿童发病和成人 MS 的研究表明，在已确诊 MS 的患者中，维生素 D 水平较低者随后复发的风险更高。这些观察性数据为 MS 中维生素 D 补充的随机对照试验提供了有力支持。
