Pendo Kevin, DeGiorgio Christopher M
Princeton University , Princeton, NJ , USA.
Department of Neurology, University of California Los Angeles , Los Angeles, CA , USA.
Front Neurol. 2016 Dec 8;7:218. doi: 10.3389/fneur.2016.00218. eCollection 2016.
There is increasing evidence supporting dietary and alternative therapies for epilepsy, including the ketogenic diet, modified Atkins diet, and omega-3 fatty acids. Vitamin D3 is actively under investigation as a potential intervention for epilepsy. Vitamin D3 is fat-soluble steroid, which shows promise in animal models of epilepsy. Basic research has shed light on the possible mechanisms by which Vitamin D3 may reduce seizures, and animal data support the efficacy of Vitamin D3 in rat and mouse models of epilepsy. Very little clinical data exist to support the treatment of human epilepsy with Vitamin D3, but positive findings from preliminary clinical trials warrant larger Phase I and II clinical trials in order to more rigorously determine the potential therapeutic value of Vitamin D3 as a treatment for human epilepsy.
越来越多的证据支持用于癫痫的饮食和替代疗法，包括生酮饮食、改良阿特金斯饮食和ω-3脂肪酸。维生素D3作为癫痫的一种潜在干预措施正在积极研究中。维生素D3是一种脂溶性类固醇，在癫痫动物模型中显示出前景。基础研究揭示了维生素D3可能减少癫痫发作的潜在机制，动物数据支持维生素D3在大鼠和小鼠癫痫模型中的疗效。目前几乎没有临床数据支持用维生素D3治疗人类癫痫，但初步临床试验的阳性结果值得开展更大规模的I期和II期临床试验，以便更严格地确定维生素D3作为人类癫痫治疗方法的潜在治疗价值。
