Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Urology. 2011 Dec;78(6):1248-56. doi: 10.1016/j.urology.2011.05.004. Epub 2011 Jul 18.
To investigate the role of stenting after uncomplicated ureteroscopy.
This was a systematic review and meta-analysis of randomized controlled trials from MEDLINE, the Cochrane Central Search Library, and the EMBASE database. All of the studies reported various outcomes with or without stenting after ureteroscopy.
Fourteen trials were identified. As there was significant heterogeneity in pain assessment, difference in postoperative pain between the stent and nonstent groups was not clear. The incidence of dysuria, frequency, and hematuria was statistically significantly higher in stent group (relative risk [RR] 1.91, 95% confidence interval [95% CI] 1.18-3.08, dysuria; RR 2.23, 95% CI 1.48-3.36, frequency and urgency; RR 2.26, 95% CI 1.20-4.24, hematuria). There was no statistically significant difference in the postoperative analgesia requirement, urinary tract infections, postoperative fever, stone-free rate, and ureteral stricture between groups. There was a decreased tendency toward unplanned medical visits or hospital readmission in the stent group (RR 0.60, 95% CI .33-1.11), but the difference was not statistically significant. Combined analysis of the trials only used holmium laser or pneumatic lithotripsy showed no statistically significantly difference in unplanned medical visits between groups. Five studies found that ureteral stenting increased the expenses. Operation duration was significantly longer in the stent group (weighted mean difference 4.25, 95% CI 1.10-7.40).
A meta-analysis of the present literature revealed much benefit in the nonstent patient group. However, considering different outcome measures, marked clinical heterogeneity and various quality of, including trials, the place of stenting after uncomplicated ureteroscopy remains unclear.
探讨单纯输尿管镜术后支架置入的作用。
这是一项对 MEDLINE、Cochrane 中央搜索库和 EMBASE 数据库进行的系统评价和荟萃分析。所有研究均报告了单纯输尿管镜术后支架置入与否的各种结局。
共确定了 14 项试验。由于疼痛评估存在显著异质性,支架组与非支架组术后疼痛差异不明确。支架组的尿痛、频度和血尿发生率明显更高(相对风险 [RR] 1.91,95%置信区间 [95%CI] 1.18-3.08,尿痛;RR 2.23,95%CI 1.48-3.36,频度和急迫感;RR 2.26,95%CI 1.20-4.24,血尿)。两组术后镇痛需求、尿路感染、术后发热、结石清除率和输尿管狭窄无统计学差异。支架组非计划性就诊或再入院的趋势降低(RR 0.60,95%CI.33-1.11),但差异无统计学意义。仅对使用钬激光或气压弹道碎石术的试验进行联合分析,两组间非计划性就诊无统计学差异。5 项研究发现输尿管支架置入增加了费用。支架组的手术时间明显更长(加权均数差 4.25,95%CI 1.10-7.40)。
对现有文献的荟萃分析显示,非支架患者组获益更多。然而,考虑到不同的结局指标、显著的临床异质性和不同的质量,包括试验,单纯输尿管镜术后支架的放置位置仍不明确。