Biochemistry Department, Science College, King Saud University, Riyadh, Saudi Arabia; Autism Research and Treatment Center, King Saud University, Riyadh, Saudi Arabia; Shaik AL-Amodi Autism Research Chair, King Saud University, Riyadh, Saudi Arabia.
Biochemistry Department, Science College, King Saud University, Riyadh, Saudi Arabia; Autism Research and Treatment Center, King Saud University, Riyadh, Saudi Arabia; Shaik AL-Amodi Autism Research Chair, King Saud University, Riyadh, Saudi Arabia.
Clin Biochem. 2011 Sep;44(13):1116-1120. doi: 10.1016/j.clinbiochem.2011.06.982. Epub 2011 Jul 6.
This study aims to clarify the relationship between blood Pb(2+) concentration as a ubiquitous environmental pollutant and plasma neurotransmitters as biochemical parameters that reflect brain function in Saudi autistic patients.
RBC's lead content together with plasma concentration of gamma aminobutyric acid (GABA), serotonin (5HT) and dopamine (DA) were measured in 25 Saudi autistic patients and compared to 16 age-matching control samples.
The obtained data recorded that Saudi autistic patients have a remarkable higher levels of Pb(2+) and significantly elevated levels of GABA, 5HT and DA compared to healthy subjects. ROC analysis revealed satisfactory values of specificity and sensitivity of the measured parameters.
This study suggests that postnatal lead toxicity in autistic patients of Saudi Arabia could represent a causative factor in the pathogenesis of autism. Elevated GABA, 5HT and DA were discussed in relation to the chronic lead toxicity recorded in the investigated autistic samples.
本研究旨在阐明作为一种普遍存在的环境污染物的血铅（Pb（2+））浓度与血浆神经递质之间的关系，这些神经递质是反映沙特自闭症患者脑功能的生化参数。
测量了 25 例沙特自闭症患者的 RBC 铅含量以及血浆 γ-氨基丁酸（GABA）、5-羟色胺（5HT）和多巴胺（DA）浓度，并与 16 例年龄匹配的对照组进行了比较。
所得数据记录显示，与健康受试者相比，沙特自闭症患者的 Pb（2+）水平显著升高，GABA、5HT 和 DA 水平显著升高。ROC 分析显示，所测参数的特异性和敏感性具有满意的值。
本研究表明，沙特自闭症患者的产后铅毒性可能是自闭症发病机制中的一个致病因素。在所研究的自闭症样本中记录到慢性铅毒性时，讨论了 GABA、5HT 和 DA 的升高。
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