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Population structure can inflate SNP-based heritability estimates.

作者信息

Browning Sharon R, Browning Brian L

出版信息

Am J Hum Genet. 2011 Jul 15;89(1):191-3; author reply 193-5. doi: 10.1016/j.ajhg.2011.05.025.

Abstract
摘要

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本文引用的文献

1
Estimating missing heritability for disease from genome-wide association studies.
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2
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3
GCTA: a tool for genome-wide complex trait analysis.
Am J Hum Genet. 2011 Jan 7;88(1):76-82. doi: 10.1016/j.ajhg.2010.11.011. Epub 2010 Dec 17.
4
Common SNPs explain a large proportion of the heritability for human height.
Nat Genet. 2010 Jul;42(7):565-9. doi: 10.1038/ng.608. Epub 2010 Jun 20.
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Variance component model to account for sample structure in genome-wide association studies.
Nat Genet. 2010 Apr;42(4):348-54. doi: 10.1038/ng.548. Epub 2010 Mar 7.
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Categorization of humans in biomedical research: genes, race and disease.
Genome Biol. 2002 Jul 1;3(7):comment2007. doi: 10.1186/gb-2002-3-7-comment2007.

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